Difference between revisions of "Journal:Laboratory information management system for the biosafety laboratory: Safety and efficiency"

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A [[laboratory information management system]] (LIMS) is a computerized system that collects, processes, and stores [[laboratory]]-generated data and [[information]]. Though the LIMS was initially developed to automate the management of experimental data, it now has the potential to develop into the digital hub of many laboratory activities.<ref>{{Cite journal |last=Gibbon |first=Gerst A. |date=1996-05 |title=A brief history of LIMS |url=https://linkinghub.elsevier.com/retrieve/pii/1381141X9500024K |journal=Laboratory Automation & Information Management |language=en |volume=32 |issue=1 |pages=1–5 |doi=10.1016/1381-141X(95)00024-K}}</ref><ref name=":0">{{Cite journal |last=Goodman |first=N. |last2=Rozen |first2=S. |last3=Stein |first3=L. D. |date=1998 |title=The LabFlow system for workflow management in large scale biology research laboratories |url=https://pubmed.ncbi.nlm.nih.gov/9783211 |journal=Proceedings. International Conference on Intelligent Systems for Molecular Biology |volume=6 |pages=69–77 |issn=1553-0833 |pmid=9783211}}</ref><ref name=":1">{{Cite journal |last=Ludäscher |first=Bertram |last2=Altintas |first2=Ilkay |last3=Berkley |first3=Chad |last4=Higgins |first4=Dan |last5=Jaeger |first5=Efrat |last6=Jones |first6=Matthew |last7=Lee |first7=Edward A. |last8=Tao |first8=Jing |last9=Zhao |first9=Yang |date=2006-08-25 |title=Scientific workflow management and the Kepler system |url=https://onlinelibrary.wiley.com/doi/10.1002/cpe.994 |journal=Concurrency and Computation: Practice and Experience |language=en |volume=18 |issue=10 |pages=1039–1065 |doi=10.1002/cpe.994 |issn=1532-0626}}</ref><ref name=":2">{{Cite journal |last=Skobelev |first=D. O. |last2=Zaytseva |first2=T. M. |last3=Kozlov |first3=A. D. |last4=Perepelitsa |first4=V. L. |last5=Makarova |first5=A. S. |date=2011-01 |title=Laboratory information management systems in the work of the analytic laboratory |url=http://link.springer.com/10.1007/s11018-011-9638-7 |journal=Measurement Techniques |language=en |volume=53 |issue=10 |pages=1182–1189 |doi=10.1007/s11018-011-9638-7 |issn=0543-1972}}</ref> Inside the lab, by deeply entwining the LIMS and highly-automated laboratory equipment, researchers are even able to program robots (for example, the Biomek series from Beckman Coulter) to execute iterative experiments without any human operation.<ref>{{Cite journal |last=McDonald |first=Michael J. |last2=Rice |first2=Daniel P. |last3=Desai |first3=Michael M. |date=2016-03 |title=Sex speeds adaptation by altering the dynamics of molecular evolution |url=http://www.nature.com/articles/nature17143 |journal=Nature |language=en |volume=531 |issue=7593 |pages=233–236 |doi=10.1038/nature17143 |issn=0028-0836 |pmc=PMC4855304 |pmid=26909573}}</ref> Outside the lab, many current LIMS in [[Clinical laboratory|clinical]] and analytical labs have greatly accelerated the process of releasing test results to the customer because of their network-based reporting system.<ref name=":2" /> Regardless of the specific functions a LIMS possesses, the ultimate purpose of the LIMS is to save human labor and improve [[data quality]] (i.e., accuracy, reliability, and timeliness).<ref>{{Cite book |last=Organization |first=World Health |last2=World Health Organization |first2=Centers for Disease Control and Prevention (U.S.) |last3=World Health Organization |last4=Clinical and Laboratory Standards Institute |date=2011 |title=Laboratory Quality Management System |url=https://public.ebookcentral.proquest.com/choice/publicfullrecord.aspx?p=1142071 |publisher=World Health Organization |place=Geneva |isbn=978-92-4-068857-5 |oclc=1162457940}}</ref>
A [[laboratory information management system]] (LIMS) is a computerized system that collects, processes, and stores [[laboratory]]-generated data and [[information]]. Though the LIMS was initially developed to automate the management of experimental data, it now has the potential to develop into the digital hub of many laboratory activities.<ref>{{Cite journal |last=Gibbon |first=Gerst A. |date=1996-05 |title=A brief history of LIMS |url=https://linkinghub.elsevier.com/retrieve/pii/1381141X9500024K |journal=Laboratory Automation & Information Management |language=en |volume=32 |issue=1 |pages=1–5 |doi=10.1016/1381-141X(95)00024-K}}</ref><ref name=":0">{{Cite journal |last=Goodman |first=N. |last2=Rozen |first2=S. |last3=Stein |first3=L. D. |date=1998 |title=The LabFlow system for workflow management in large scale biology research laboratories |url=https://pubmed.ncbi.nlm.nih.gov/9783211 |journal=Proceedings. International Conference on Intelligent Systems for Molecular Biology |volume=6 |pages=69–77 |issn=1553-0833 |pmid=9783211}}</ref><ref name=":1">{{Cite journal |last=Ludäscher |first=Bertram |last2=Altintas |first2=Ilkay |last3=Berkley |first3=Chad |last4=Higgins |first4=Dan |last5=Jaeger |first5=Efrat |last6=Jones |first6=Matthew |last7=Lee |first7=Edward A. |last8=Tao |first8=Jing |last9=Zhao |first9=Yang |date=2006-08-25 |title=Scientific workflow management and the Kepler system |url=https://onlinelibrary.wiley.com/doi/10.1002/cpe.994 |journal=Concurrency and Computation: Practice and Experience |language=en |volume=18 |issue=10 |pages=1039–1065 |doi=10.1002/cpe.994 |issn=1532-0626}}</ref><ref name=":2">{{Cite journal |last=Skobelev |first=D. O. |last2=Zaytseva |first2=T. M. |last3=Kozlov |first3=A. D. |last4=Perepelitsa |first4=V. L. |last5=Makarova |first5=A. S. |date=2011-01 |title=Laboratory information management systems in the work of the analytic laboratory |url=http://link.springer.com/10.1007/s11018-011-9638-7 |journal=Measurement Techniques |language=en |volume=53 |issue=10 |pages=1182–1189 |doi=10.1007/s11018-011-9638-7 |issn=0543-1972}}</ref> Inside the lab, by deeply entwining the LIMS and highly-automated laboratory equipment, researchers are even able to program robots (for example, the Biomek series from Beckman Coulter) to execute iterative experiments without any human operation.<ref>{{Cite journal |last=McDonald |first=Michael J. |last2=Rice |first2=Daniel P. |last3=Desai |first3=Michael M. |date=2016-03 |title=Sex speeds adaptation by altering the dynamics of molecular evolution |url=http://www.nature.com/articles/nature17143 |journal=Nature |language=en |volume=531 |issue=7593 |pages=233–236 |doi=10.1038/nature17143 |issn=0028-0836 |pmc=PMC4855304 |pmid=26909573}}</ref> Outside the lab, many current LIMS in [[Clinical laboratory|clinical]] and analytical labs have greatly accelerated the process of releasing test results to the customer because of their network-based reporting system.<ref name=":2" /> Regardless of the specific functions a LIMS possesses, the ultimate purpose of the LIMS is to save human labor and improve [[data quality]] (i.e., accuracy, reliability, and timeliness).<ref>{{Cite book |last=Organization |first=World Health |last2=World Health Organization |first2=Centers for Disease Control and Prevention (U.S.) |last3=World Health Organization |last4=Clinical and Laboratory Standards Institute |date=2011 |title=Laboratory Quality Management System |url=https://public.ebookcentral.proquest.com/choice/publicfullrecord.aspx?p=1142071 |publisher=World Health Organization |place=Geneva |isbn=978-92-4-068857-5 |oclc=1162457940}}</ref>


Although the importance of a LIMS in a lab was quite low initially, with the rapid development of computer and network technologies, the LIMS had gradually evolved to play more diverse roles and become an irreplaceable part in many labs. The range of LIMS users has expanded as well, from mostly analytical labs to diagnostic [[biosafety]] laboratories (BSLs) of specific function, as well as more general research labs.<ref name=":0" /><ref name=":1" /><ref>{{Cite journal |last=Melo |first=Alexandre |last2=Faria-Campos |first2=Alessandra |last3=DeLaat |first3=Daiane |last4=Keller |first4=Rodrigo |last5=Abreu |first5=Vinícius |last6=Campos |first6=Sérgio |date=2010 |title=SIGLa: an adaptable LIMS for multiple laboratories |url=http://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-11-S5-S8 |journal=BMC Genomics |language=en |volume=11 |issue=Suppl 5 |pages=S8 |doi=10.1186/1471-2164-11-S5-S8 |issn=1471-2164 |pmc=PMC3045801 |pmid=21210974}}</ref><ref>{{Cite journal |last=IGI Testing Consortium |last2=Amen |first2=Alexandra M. |last3=Barry |first3=Kerrie W. |last4=Boyle |first4=John M. |last5=Brook |first5=Cara E. |last6=Choo |first6=Seunga |last7=Cornmesser |first7=L. T. |last8=Dilworth |first8=David J. |last9=Doudna |first9=Jennifer A. |last10=Ehrenberg |first10=Alexander J. |last11=Fedrigo |first11=Indro |date=2020-07 |title=Blueprint for a pop-up SARS-CoV-2 testing lab |url=http://www.nature.com/articles/s41587-020-0583-3 |journal=Nature Biotechnology |language=en |volume=38 |issue=7 |pages=791–797 |doi=10.1038/s41587-020-0583-3 |issn=1087-0156}}</ref>
Although the importance of a LIMS in a lab was quite low initially, with the rapid development of computer and network technologies, the LIMS had gradually evolved to play more diverse roles and become an irreplaceable part in many labs. The range of LIMS users has expanded as well, from mostly analytical labs to diagnostic [[biosafety]] laboratories (BSLs) of specific function, as well as more general research labs.<ref name=":0" /><ref name=":1" /><ref name=":3">{{Cite journal |last=Melo |first=Alexandre |last2=Faria-Campos |first2=Alessandra |last3=DeLaat |first3=Daiane |last4=Keller |first4=Rodrigo |last5=Abreu |first5=Vinícius |last6=Campos |first6=Sérgio |date=2010 |title=SIGLa: an adaptable LIMS for multiple laboratories |url=http://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-11-S5-S8 |journal=BMC Genomics |language=en |volume=11 |issue=Suppl 5 |pages=S8 |doi=10.1186/1471-2164-11-S5-S8 |issn=1471-2164 |pmc=PMC3045801 |pmid=21210974}}</ref><ref>{{Cite journal |last=IGI Testing Consortium |last2=Amen |first2=Alexandra M. |last3=Barry |first3=Kerrie W. |last4=Boyle |first4=John M. |last5=Brook |first5=Cara E. |last6=Choo |first6=Seunga |last7=Cornmesser |first7=L. T. |last8=Dilworth |first8=David J. |last9=Doudna |first9=Jennifer A. |last10=Ehrenberg |first10=Alexander J. |last11=Fedrigo |first11=Indro |date=2020-07 |title=Blueprint for a pop-up SARS-CoV-2 testing lab |url=http://www.nature.com/articles/s41587-020-0583-3 |journal=Nature Biotechnology |language=en |volume=38 |issue=7 |pages=791–797 |doi=10.1038/s41587-020-0583-3 |issn=1087-0156}}</ref>


Nevertheless, the functions of all current LIMS, to our knowledge, do not address the major concern of biological safety and security in biosafety labs. This is even true for those LIMS currently used in BSLs. Although the modern LIMS has reduced a number of human factors from certain experimental activities, few if any have actually increased the general safety of the BSL as these systems do not contain any safety- and security-control mechanisms. The focus of a traditional LIMS, whether it is used in a BSL or not, is still to better facilitate lab staff performing experiments. Even the [[electronic laboratory notebook]] (ELN), a tool widely appreciated by BSL staff, was not designed for but merely happened to suit the working environment of BSLs. As such, we do not currently have any digital systems that can help a BSL manage its biosafety information. At the same time, biosafety-related information has been collected, stored, and transmitted in digital form in BSLs since at least 2000, and the amount of digital biosafety information is growing, when compared to paper-based information.<ref>{{Citation |last=Stuart |first=Ralph |last2=Stewart |first2=James |last3=Herrick |first3=Robert |date=2019-03-29 |editor-last=Mansdorf |editor-first=S. Z. |title=INFORMATION RESOURCES FOR OCCUPATIONAL SAFETY AND HEALTH PROFESSIONALS |url=https://onlinelibrary.wiley.com/doi/10.1002/9781119581482.ch2 |work=Handbook of Occupational Safety and Health |language=en |publisher=John Wiley & Sons, Inc. |place=Hoboken, NJ, USA |pages=37–48 |doi=10.1002/9781119581482.ch2 |isbn=978-1-119-58148-2 |accessdate=2021-10-22}}</ref> This has resulted in a strange situation, onw where biosafety information itself is highly digitalized, yet there is no centralized system designed to better organize that electronic information and enable laboratorians to use it appropriately. Most information typically stays in the form of isolated electronic documents on either a local computer or hosted on a local network, and the search and retrieval of the information is usually complicated. For example, when a safety document is requested by a user, the search, deployment, use, and dissemination of the document is largely done on an individual basis, via a not-well-indexed information system and an unrelated transmission system like email or even paper-based messaging. Hence, the [[information management]] system of biosafety labs—if the system even exists—is ineffective, inefficient, and cannot satisfy the needs of the modern biosafety lab. We therefore believe that a specific information management system for biosafety laboratories that is able to improve the safety and efficiency of these laboratories is a necessity.
Nevertheless, the functions of all current LIMS, to our knowledge, do not address the major concern of biological safety and security in biosafety labs. This is even true for those LIMS currently used in BSLs. Although the modern LIMS has reduced a number of human factors from certain experimental activities, few if any have actually increased the general safety of the BSL as these systems do not contain any safety- and security-control mechanisms. The focus of a traditional LIMS, whether it is used in a BSL or not, is still to better facilitate lab staff performing experiments. Even the [[electronic laboratory notebook]] (ELN), a tool widely appreciated by BSL staff, was not designed for but merely happened to suit the working environment of BSLs. As such, we do not currently have any digital systems that can help a BSL manage its biosafety information. At the same time, biosafety-related information has been collected, stored, and transmitted in digital form in BSLs since at least 2000, and the amount of digital biosafety information is growing, when compared to paper-based information.<ref>{{Citation |last=Stuart |first=Ralph |last2=Stewart |first2=James |last3=Herrick |first3=Robert |date=2019-03-29 |editor-last=Mansdorf |editor-first=S. Z. |title=INFORMATION RESOURCES FOR OCCUPATIONAL SAFETY AND HEALTH PROFESSIONALS |url=https://onlinelibrary.wiley.com/doi/10.1002/9781119581482.ch2 |work=Handbook of Occupational Safety and Health |language=en |publisher=John Wiley & Sons, Inc. |place=Hoboken, NJ, USA |pages=37–48 |doi=10.1002/9781119581482.ch2 |isbn=978-1-119-58148-2 |accessdate=2021-10-22}}</ref> This has resulted in a strange situation, onw where biosafety information itself is highly digitalized, yet there is no centralized system designed to better organize that electronic information and enable laboratorians to use it appropriately. Most information typically stays in the form of isolated electronic documents on either a local computer or hosted on a local network, and the search and retrieval of the information is usually complicated. For example, when a safety document is requested by a user, the search, deployment, use, and dissemination of the document is largely done on an individual basis, via a not-well-indexed information system and an unrelated transmission system like email or even paper-based messaging. Hence, the [[information management]] system of biosafety labs—if the system even exists—is ineffective, inefficient, and cannot satisfy the needs of the modern biosafety lab. We therefore believe that a specific information management system for biosafety laboratories that is able to improve the safety and efficiency of these laboratories is a necessity.
==A laboratory information management system for the biosafety laboratory==
This paper proposes a laboratory information management system for the modern biosafety laboratory (BSL-LIMS), specifically designed for both [[Biosafety level|high-level biosafety]] labs (BSL-3 or -4) and basic research BSLs. Since the BSL-LIMS has its root in the specific needs of BSLs, the focus of the system is different from the traditional LIMS. Biosafety and biosecurity are made the primary concerns in the BSL-LIMS, with similar if not more importance than improving efficiency.<ref>{{Cite journal |last=Trevan |first=Tim |date=2015-11 |title=Biological research: Rethink biosafety |url=http://www.nature.com/articles/527155a |journal=Nature |language=en |volume=527 |issue=7577 |pages=155–158 |doi=10.1038/527155a |issn=0028-0836}}</ref>
Biosafety in laboratories has two major considerations: the safety of those who work in the lab in some capacity and the safety of the overall environment.<ref>{{Cite book |date=2004 |editor-last=World Health Organization |title=Laboratory biosafety manual |url=https://www.worldcat.org/title/mediawiki/oclc/ocm57658996 |edition=3rd ed |publisher=World Health Organization |place=Geneva |isbn=978-92-4-154650-8 |oclc=ocm57658996}}</ref> As such, the aim of a BSL is to keep both the personnel and environment safe before, during, and after experiments and other analyses. If there are any unavoidable safety risks in the course of a research project, then the risks must be reduced to an acceptable and controllable degree before the start of the project, and be kept this way until the end of it; otherwise, the project should be abandoned rather than allowed to begin. Hence, as a part of BSL activities, the design of the BSL-LIMS has to comply with the safety standards set by BSLs. Since biosafety is a precondition for experiments in BSLs, the focus of the corresponding LIMS shifts from post-experimental information (i.e., results) management to pre-experimental information (i.e., preparation) management. Even though the overall framework of the BSL-LIMS might look similar to that of a traditional LIMS, their contents would be very different.
Information management in a BSL can be divided into four categories:
#Project management
#Personnel administration
#Experimental material management
#Equipment management
As such, any information management system would involve a large amount of information collection and exchange within and between different categories. Many checkpoints would need to be set up for the sake of safety control. These interconnected information flows and checkpoints would then form an elaborate network whose structure can be simplified to Petri Nets<ref name=":0" />, with laboratory data or information as places and research or audit activities as transitions. Since laboratory [[workflow]] management has already been a part of many regular research labs’ information management systems<ref name=":0" /><ref name=":1" /><ref name=":3" />, some modules in these traditional LIMS (e.g., the management of samples, materials, or equipment) may be used by the BSL-LIMS, though new databases on biosafety information should be added, and existing structures probably need to be redesigned in order to meet the new demands for improving biosafety and biosecurity.
===Project management===




Revision as of 19:39, 22 October 2021

Full article title Laboratory information management system for the biosafety laboratory: Safety and efficiency
Journal Journal of Biosafety and Biosecurity
Author(s) Sun, Dingzhong; Wu, Linhuan; Fan, Guomei
Author affiliation(s) Institute of Microbiology Chinese Academy of Sciences
Primary contact Email: wulh at im dot ac dot cn
Year published 2021
Volume and issue 3(1)
Page(s) 28–34
DOI 10.1016/j.jobb.2021.03.001
ISSN 2588-9338
Distribution license Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Website https://www.sciencedirect.com/science/article/pii/S2588933821000042
Download https://www.sciencedirect.com/science/article/pii/S2588933821000042/pdfft (PDF)
Emblem-important-yellow.svg This article should be considered a work in progress and incomplete. Consider this article incomplete until this notice is removed.

Abstract

The laboratory information management system (LIMS) has been widely used to facilitate laboratory activities. However, the current LIMS does not contain functions to improve the safety of laboratory work, which is a major concern of biosafety laboratories (BSLs). With significant biosafety information needing to be managed and an increasing number of biosafety-related research projects underway, it is worthy of expanding the current framework of LIMS and building a system that is more suitable for BSL usage. Such a system should carefully trade off between the safety and efficiency of regular lab activities, allowing laboratory staff to conduct their research as freely as possible while also ensuring their and the environment’s safety. In order to achieve this goal, relevant information on the type of research, laboratory personnel, experimental materials, and experimental equipment must be collected and fully utilized by a centralized system and its databases.

Keywords: laboratory information management system, biosafety, biological research laboratory, laboratory safety, workflow management

Introduction

A laboratory information management system (LIMS) is a computerized system that collects, processes, and stores laboratory-generated data and information. Though the LIMS was initially developed to automate the management of experimental data, it now has the potential to develop into the digital hub of many laboratory activities.[1][2][3][4] Inside the lab, by deeply entwining the LIMS and highly-automated laboratory equipment, researchers are even able to program robots (for example, the Biomek series from Beckman Coulter) to execute iterative experiments without any human operation.[5] Outside the lab, many current LIMS in clinical and analytical labs have greatly accelerated the process of releasing test results to the customer because of their network-based reporting system.[4] Regardless of the specific functions a LIMS possesses, the ultimate purpose of the LIMS is to save human labor and improve data quality (i.e., accuracy, reliability, and timeliness).[6]

Although the importance of a LIMS in a lab was quite low initially, with the rapid development of computer and network technologies, the LIMS had gradually evolved to play more diverse roles and become an irreplaceable part in many labs. The range of LIMS users has expanded as well, from mostly analytical labs to diagnostic biosafety laboratories (BSLs) of specific function, as well as more general research labs.[2][3][7][8]

Nevertheless, the functions of all current LIMS, to our knowledge, do not address the major concern of biological safety and security in biosafety labs. This is even true for those LIMS currently used in BSLs. Although the modern LIMS has reduced a number of human factors from certain experimental activities, few if any have actually increased the general safety of the BSL as these systems do not contain any safety- and security-control mechanisms. The focus of a traditional LIMS, whether it is used in a BSL or not, is still to better facilitate lab staff performing experiments. Even the electronic laboratory notebook (ELN), a tool widely appreciated by BSL staff, was not designed for but merely happened to suit the working environment of BSLs. As such, we do not currently have any digital systems that can help a BSL manage its biosafety information. At the same time, biosafety-related information has been collected, stored, and transmitted in digital form in BSLs since at least 2000, and the amount of digital biosafety information is growing, when compared to paper-based information.[9] This has resulted in a strange situation, onw where biosafety information itself is highly digitalized, yet there is no centralized system designed to better organize that electronic information and enable laboratorians to use it appropriately. Most information typically stays in the form of isolated electronic documents on either a local computer or hosted on a local network, and the search and retrieval of the information is usually complicated. For example, when a safety document is requested by a user, the search, deployment, use, and dissemination of the document is largely done on an individual basis, via a not-well-indexed information system and an unrelated transmission system like email or even paper-based messaging. Hence, the information management system of biosafety labs—if the system even exists—is ineffective, inefficient, and cannot satisfy the needs of the modern biosafety lab. We therefore believe that a specific information management system for biosafety laboratories that is able to improve the safety and efficiency of these laboratories is a necessity.

A laboratory information management system for the biosafety laboratory

This paper proposes a laboratory information management system for the modern biosafety laboratory (BSL-LIMS), specifically designed for both high-level biosafety labs (BSL-3 or -4) and basic research BSLs. Since the BSL-LIMS has its root in the specific needs of BSLs, the focus of the system is different from the traditional LIMS. Biosafety and biosecurity are made the primary concerns in the BSL-LIMS, with similar if not more importance than improving efficiency.[10]

Biosafety in laboratories has two major considerations: the safety of those who work in the lab in some capacity and the safety of the overall environment.[11] As such, the aim of a BSL is to keep both the personnel and environment safe before, during, and after experiments and other analyses. If there are any unavoidable safety risks in the course of a research project, then the risks must be reduced to an acceptable and controllable degree before the start of the project, and be kept this way until the end of it; otherwise, the project should be abandoned rather than allowed to begin. Hence, as a part of BSL activities, the design of the BSL-LIMS has to comply with the safety standards set by BSLs. Since biosafety is a precondition for experiments in BSLs, the focus of the corresponding LIMS shifts from post-experimental information (i.e., results) management to pre-experimental information (i.e., preparation) management. Even though the overall framework of the BSL-LIMS might look similar to that of a traditional LIMS, their contents would be very different.

Information management in a BSL can be divided into four categories:

  1. Project management
  2. Personnel administration
  3. Experimental material management
  4. Equipment management

As such, any information management system would involve a large amount of information collection and exchange within and between different categories. Many checkpoints would need to be set up for the sake of safety control. These interconnected information flows and checkpoints would then form an elaborate network whose structure can be simplified to Petri Nets[2], with laboratory data or information as places and research or audit activities as transitions. Since laboratory workflow management has already been a part of many regular research labs’ information management systems[2][3][7], some modules in these traditional LIMS (e.g., the management of samples, materials, or equipment) may be used by the BSL-LIMS, though new databases on biosafety information should be added, and existing structures probably need to be redesigned in order to meet the new demands for improving biosafety and biosecurity.

Project management

References

  1. ↑ Gibbon, Gerst A. (1 May 1996). "A brief history of LIMS" (in en). Laboratory Automation & Information Management 32 (1): 1–5. doi:10.1016/1381-141X(95)00024-K. https://linkinghub.elsevier.com/retrieve/pii/1381141X9500024K. 
  2. ↑ 2.0 2.1 2.2 2.3 Goodman, N.; Rozen, S.; Stein, L. D. (1998). "The LabFlow system for workflow management in large scale biology research laboratories". Proceedings. International Conference on Intelligent Systems for Molecular Biology 6: 69–77. ISSN 1553-0833. PMID 9783211. https://pubmed.ncbi.nlm.nih.gov/9783211. 
  3. ↑ 3.0 3.1 3.2 Ludäscher, Bertram; Altintas, Ilkay; Berkley, Chad; Higgins, Dan; Jaeger, Efrat; Jones, Matthew; Lee, Edward A.; Tao, Jing et al. (25 August 2006). "Scientific workflow management and the Kepler system" (in en). Concurrency and Computation: Practice and Experience 18 (10): 1039–1065. doi:10.1002/cpe.994. ISSN 1532-0626. https://onlinelibrary.wiley.com/doi/10.1002/cpe.994. 
  4. ↑ 4.0 4.1 Skobelev, D. O.; Zaytseva, T. M.; Kozlov, A. D.; Perepelitsa, V. L.; Makarova, A. S. (1 January 2011). "Laboratory information management systems in the work of the analytic laboratory" (in en). Measurement Techniques 53 (10): 1182–1189. doi:10.1007/s11018-011-9638-7. ISSN 0543-1972. http://link.springer.com/10.1007/s11018-011-9638-7. 
  5. ↑ McDonald, Michael J.; Rice, Daniel P.; Desai, Michael M. (1 March 2016). "Sex speeds adaptation by altering the dynamics of molecular evolution" (in en). Nature 531 (7593): 233–236. doi:10.1038/nature17143. ISSN 0028-0836. PMC PMC4855304. PMID 26909573. http://www.nature.com/articles/nature17143. 
  6. ↑ Organization, World Health; World Health Organization, Centers for Disease Control and Prevention (U.S.); World Health Organization; Clinical and Laboratory Standards Institute (2011). Laboratory Quality Management System. Geneva: World Health Organization. ISBN 978-92-4-068857-5. OCLC 1162457940. https://public.ebookcentral.proquest.com/choice/publicfullrecord.aspx?p=1142071. 
  7. ↑ 7.0 7.1 Melo, Alexandre; Faria-Campos, Alessandra; DeLaat, Daiane; Keller, Rodrigo; Abreu, Vinícius; Campos, Sérgio (2010). "SIGLa: an adaptable LIMS for multiple laboratories" (in en). BMC Genomics 11 (Suppl 5): S8. doi:10.1186/1471-2164-11-S5-S8. ISSN 1471-2164. PMC PMC3045801. PMID 21210974. http://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-11-S5-S8. 
  8. ↑ IGI Testing Consortium; Amen, Alexandra M.; Barry, Kerrie W.; Boyle, John M.; Brook, Cara E.; Choo, Seunga; Cornmesser, L. T.; Dilworth, David J. et al. (1 July 2020). "Blueprint for a pop-up SARS-CoV-2 testing lab" (in en). Nature Biotechnology 38 (7): 791–797. doi:10.1038/s41587-020-0583-3. ISSN 1087-0156. http://www.nature.com/articles/s41587-020-0583-3. 
  9. ↑ Stuart, Ralph; Stewart, James; Herrick, Robert (29 March 2019), Mansdorf, S. Z., ed., "INFORMATION RESOURCES FOR OCCUPATIONAL SAFETY AND HEALTH PROFESSIONALS" (in en), Handbook of Occupational Safety and Health (Hoboken, NJ, USA: John Wiley & Sons, Inc.): 37–48, doi:10.1002/9781119581482.ch2, ISBN 978-1-119-58148-2, https://onlinelibrary.wiley.com/doi/10.1002/9781119581482.ch2. Retrieved 2021-10-22 
  10. ↑ Trevan, Tim (1 November 2015). "Biological research: Rethink biosafety" (in en). Nature 527 (7577): 155–158. doi:10.1038/527155a. ISSN 0028-0836. http://www.nature.com/articles/527155a. 
  11. ↑ World Health Organization, ed. (2004). Laboratory biosafety manual (3rd ed ed.). Geneva: World Health Organization. ISBN 978-92-4-154650-8. OCLC ocm57658996. https://www.worldcat.org/title/mediawiki/oclc/ocm57658996. 

Notes

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