https://www.limswiki.org/index.php?title=Laboratory_information_management_system&feed=atom&action=historyLaboratory information management system - Revision history2024-03-28T23:54:40ZRevision history for this page on the wikiMediaWiki 1.36.1https://www.limswiki.org/index.php?title=Laboratory_information_management_system&diff=60426&oldid=prevShawndouglas: Text replacement - "Thermo Scientific" to "Thermo Scientific"2024-03-28T01:18:53Z<p>Text replacement - "<a href="/index.php?title=Thermo_Scientific&action=edit&redlink=1" class="new" title="Thermo Scientific (page does not exist)">Thermo Scientific</a>" to "<a href="/index.php/Vendor:Thermo_Scientific" title="Vendor:Thermo Scientific">Thermo Scientific</a>"</p>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>3. A LIMS is most competitive in group-centric settings (dealing with "batches" and "samples") that often deal with mostly anonymous research-specific laboratory data, whereas a LIS is usually most competitive in patient-centric settings (dealing with "subjects" and "specimens") and clinical labs.<ref name="analytica" /><ref name="lislims2">{{cite web |url=http://labsoftnews.typepad.com/lab_soft_news/2008/11/lis-vs-lims.html |title=LIS vs. LIMS: Some New Insights |author=Friedman, B. |work=Lab Soft News |date=19 November 2008 |accessdate=13 March 2024}}</ref><ref name="starlims">{{cite web |url=http://blog.starlims.com/2009/07/01/swimming-in-the-clinical-pool-why-lims-are-supplanting-old-school-clinical-lis-applications/ |archiveurl=https://web.archive.org/web/20110313145726/http://blog.starlims.com/2009/07/01/swimming-in-the-clinical-pool-why-lims-are-supplanting-old-school-clinical-lis-applications/ |title=Swimming in the Clinical Pool: Why LIMS are supplanting old-school clinical LIS applications |author=Hice, R. |publisher=STARLIMS Corporation |date=01 July 2009 |archivedate=13 March 2011 |accessdate=13 March 2024}}</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>3. A LIMS is most competitive in group-centric settings (dealing with "batches" and "samples") that often deal with mostly anonymous research-specific laboratory data, whereas a LIS is usually most competitive in patient-centric settings (dealing with "subjects" and "specimens") and clinical labs.<ref name="analytica" /><ref name="lislims2">{{cite web |url=http://labsoftnews.typepad.com/lab_soft_news/2008/11/lis-vs-lims.html |title=LIS vs. LIMS: Some New Insights |author=Friedman, B. |work=Lab Soft News |date=19 November 2008 |accessdate=13 March 2024}}</ref><ref name="starlims">{{cite web |url=http://blog.starlims.com/2009/07/01/swimming-in-the-clinical-pool-why-lims-are-supplanting-old-school-clinical-lis-applications/ |archiveurl=https://web.archive.org/web/20110313145726/http://blog.starlims.com/2009/07/01/swimming-in-the-clinical-pool-why-lims-are-supplanting-old-school-clinical-lis-applications/ |title=Swimming in the Clinical Pool: Why LIMS are supplanting old-school clinical LIS applications |author=Hice, R. |publisher=STARLIMS Corporation |date=01 July 2009 |archivedate=13 March 2011 |accessdate=13 March 2024}}</ref></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>However, these distinctions began to fade somewhat in the early 2010s as some LIMS vendors began to adopt the case-centric information management normally reserved for a LIS, blurring the lines between the two components further.<ref name="starlims" /> [[Thermo Scientific]]'s Clinical LIMS was an example of this merger of LIMS with LIS, with Dave Champagne, informatics vice president and general manager, stating: "Routine molecular diagnostics requires a convergence of the up-to-now separate systems that have managed work in the lab (the LIMS) and the clinic (the LIS). The industry is asking for, and the science is requiring, a single lab-centric solution that delivers patient-centric results."<ref name="ConvergeLimsLis">{{cite web |url=https://clpmag.com/lab-essentials/information-technology/convergence-of-lims-and-lis/ |title=Convergence of LIMS and LIS |author=Tufel, G. |work=Clinical Lab Products |publisher=MEDQOR |date=01 February 2012 |accessdate=13 March 2024}}</ref> [[Abbott Informatics Corporation]]'s STARLIMS product was another example of this LIMS/LIS merger.<ref name="StarlimsLimsLis" /> With the distinction between the two entities becoming less clear, discussions within the laboratory informatics community began to includes the question of whether or not the two entities should be considered the same.<ref name="LinkedInDifLisLims">{{cite web |url=https://www.linkedin.com/feed/update/urn:li:groupPost:2069898-98494737/ |title=What is the difference between a LIS and a LIMS? |author=Jones, J. |publisher=LinkedIn |date=March 2012 |accessdate=13 March 2024}}</ref><ref name="LinkedInLisLimsSame">{{cite web |url=http://www.linkedin.com/groups/Are-LIMS-LIS-same-thing-2069898.S.147132083 |title=Are LIMS and LIS the same thing? |author=Jones, John |publisher=LinkedIn |date=September 2012 |accessdate=07 November 2012}}{{Dead link}}</ref> {{As of|2024}}, vendors continue to recognize the historical differences between the two products while also continuing to acknowledge that some developed LIMS are taking on more of the clinical aspects usually reserved for a LIS.<ref name="AgilabFAQ">{{cite web |url=http://agilab.com/faq/ |archiveurl=https://web.archive.org/web/20190325075813/http://agilab.com/faq/ |title=FAQ: What is the difference between a LIMS and a medical laboratory quality system? |publisher=AgiLab SAS |archivedate=25 March 2019 |accessdate=13 March 2024}}</ref><ref name="ReisenwitzWhatIs17">{{cite web |url=https://www.capterra.com/resources/what-is-a-laboratory-information-management-system/ |title=What Is a Laboratory Information Management System? |author=Reisenwitz, C. |work=Capterra Medical Software Blog |publisher=Capterra, Inc |date=11 May 2017 |accessdate=13 March 2024}}</ref><ref name="CloudLISDifference16">{{cite web |url=https://cloudlims.com/lims-vs-lis/ |title=LIS vs LIMS: Uncover the Difference & Choose the Right Informatics Solution |publisher=CloudLIMS.com, LLC |date=12 October 2023 |accessdate=13 March 2024}}</ref></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>However, these distinctions began to fade somewhat in the early 2010s as some LIMS vendors began to adopt the case-centric information management normally reserved for a LIS, blurring the lines between the two components further.<ref name="starlims" /> [[<ins style="font-weight: bold; text-decoration: none;">Vendor:Thermo Scientific|</ins>Thermo Scientific]]'s Clinical LIMS was an example of this merger of LIMS with LIS, with Dave Champagne, informatics vice president and general manager, stating: "Routine molecular diagnostics requires a convergence of the up-to-now separate systems that have managed work in the lab (the LIMS) and the clinic (the LIS). The industry is asking for, and the science is requiring, a single lab-centric solution that delivers patient-centric results."<ref name="ConvergeLimsLis">{{cite web |url=https://clpmag.com/lab-essentials/information-technology/convergence-of-lims-and-lis/ |title=Convergence of LIMS and LIS |author=Tufel, G. |work=Clinical Lab Products |publisher=MEDQOR |date=01 February 2012 |accessdate=13 March 2024}}</ref> [[Abbott Informatics Corporation]]'s STARLIMS product was another example of this LIMS/LIS merger.<ref name="StarlimsLimsLis" /> With the distinction between the two entities becoming less clear, discussions within the laboratory informatics community began to includes the question of whether or not the two entities should be considered the same.<ref name="LinkedInDifLisLims">{{cite web |url=https://www.linkedin.com/feed/update/urn:li:groupPost:2069898-98494737/ |title=What is the difference between a LIS and a LIMS? |author=Jones, J. |publisher=LinkedIn |date=March 2012 |accessdate=13 March 2024}}</ref><ref name="LinkedInLisLimsSame">{{cite web |url=http://www.linkedin.com/groups/Are-LIMS-LIS-same-thing-2069898.S.147132083 |title=Are LIMS and LIS the same thing? |author=Jones, John |publisher=LinkedIn |date=September 2012 |accessdate=07 November 2012}}{{Dead link}}</ref> {{As of|2024}}, vendors continue to recognize the historical differences between the two products while also continuing to acknowledge that some developed LIMS are taking on more of the clinical aspects usually reserved for a LIS.<ref name="AgilabFAQ">{{cite web |url=http://agilab.com/faq/ |archiveurl=https://web.archive.org/web/20190325075813/http://agilab.com/faq/ |title=FAQ: What is the difference between a LIMS and a medical laboratory quality system? |publisher=AgiLab SAS |archivedate=25 March 2019 |accessdate=13 March 2024}}</ref><ref name="ReisenwitzWhatIs17">{{cite web |url=https://www.capterra.com/resources/what-is-a-laboratory-information-management-system/ |title=What Is a Laboratory Information Management System? |author=Reisenwitz, C. |work=Capterra Medical Software Blog |publisher=Capterra, Inc |date=11 May 2017 |accessdate=13 March 2024}}</ref><ref name="CloudLISDifference16">{{cite web |url=https://cloudlims.com/lims-vs-lis/ |title=LIS vs LIMS: Uncover the Difference & Choose the Right Informatics Solution |publisher=CloudLIMS.com, LLC |date=12 October 2023 |accessdate=13 March 2024}}</ref></div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Regulations, standards, and best practices affecting LIMS development and use==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Regulations, standards, and best practices affecting LIMS development and use==</div></td></tr>
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</table>Shawndouglashttps://www.limswiki.org/index.php?title=Laboratory_information_management_system&diff=58795&oldid=prevShawndouglas: /* History */ Fix2024-03-20T15:36:41Z<p><span dir="auto"><span class="autocomment">History: </span> Fix</span></p>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Up until the late 1970s, management of laboratory samples and their associated analysis and reporting was a time-consuming manual processes often riddled with transcription errors. This gave some organizations impetus to streamline the collection of data and how it was reported. Custom in-house solutions were developed by a few individual laboratories, while some enterprising entities at the same time sought to develop a more commercial reporting solution in the form of special instrument-based systems.<ref name="LIMSHistory">{{cite journal |title=A brief history of LIMS |journal=Laboratory Automation and Information Management |author=Gibbon, G.A. |volume=32 |issue=1 |pages=1–5 |year=1996 |doi=10.1016/1381-141X(95)00024-K}}</ref> </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Up until the late 1970s, management of laboratory samples and their associated analysis and reporting was a time-consuming manual processes often riddled with transcription errors. This gave some organizations impetus to streamline the collection of data and how it was reported. Custom in-house solutions were developed by a few individual laboratories, while some enterprising entities at the same time sought to develop a more commercial reporting solution in the form of special instrument-based systems.<ref name="LIMSHistory">{{cite journal |title=A brief history of LIMS |journal=Laboratory Automation and Information Management |author=Gibbon, G.A. |volume=32 |issue=1 |pages=1–5 |year=1996 |doi=10.1016/1381-141X(95)00024-K}}</ref> </div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>In 1982, the first generation of LIMS was introduced in the form of a single centralized minicomputer, which offered laboratories the first opportunity to utilize automated reporting tools. As the interest in these early LIMS grew, industry leaders like Gerst Gibbon of the Federal Energy Technology Centre in Pittsburgh began planting the seeds through LIMS-related conferences. By 1988, the second-generation commercial offerings were tapping into [[<del style="font-weight: bold; text-decoration: none;">Relational database</del>|relational databases]] to expand LIMS into more application-specific territory, and international LIMS conferences were in full swing. As personal computers became more powerful and prominent, a third generation of LIMS emerged in the early 1990s. These new LIMS took advantage of the developing client/server architecture, allowing laboratories to implement better data processing and exchanges.<ref name="LIMSHistory" /></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>In 1982, the first generation of LIMS was introduced in the form of a single centralized minicomputer, which offered laboratories the first opportunity to utilize automated reporting tools. As the interest in these early LIMS grew, industry leaders like Gerst Gibbon of the Federal Energy Technology Centre in Pittsburgh began planting the seeds through LIMS-related conferences. By 1988, the second-generation commercial offerings were tapping into [[<ins style="font-weight: bold; text-decoration: none;">Database</ins>|relational databases]] to expand LIMS into more application-specific territory, and international LIMS conferences were in full swing. As personal computers became more powerful and prominent, a third generation of LIMS emerged in the early 1990s. These new LIMS took advantage of the developing client/server architecture, allowing laboratories to implement better data processing and exchanges.<ref name="LIMSHistory" /></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>By 1995, the client/server tools had developed to the point of allowing processing of data anywhere on the network. Web-enabled LIMS were introduced the following year, enabling researchers to extend operations outside the confines of the laboratory. From 1996 to 2002, additional functionality was included in LIMS, from wireless networking capabilities and georeferencing of samples, to the adoption of [[XML]] standards and the development of internet-based purchasing.<ref name="LIMSHistory" /></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>By 1995, the client/server tools had developed to the point of allowing processing of data anywhere on the network. Web-enabled LIMS were introduced the following year, enabling researchers to extend operations outside the confines of the laboratory. From 1996 to 2002, additional functionality was included in LIMS, from wireless networking capabilities and georeferencing of samples, to the adoption of [[XML]] standards and the development of internet-based purchasing.<ref name="LIMSHistory" /></div></td></tr>
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</table>Shawndouglashttps://www.limswiki.org/index.php?title=Laboratory_information_management_system&diff=58762&oldid=prevShawndouglas: /* Regulations, standards, and best practices affecting LIMS development and use */ Typo2024-03-15T17:03:36Z<p><span dir="auto"><span class="autocomment">Regulations, standards, and best practices affecting LIMS development and use: </span> Typo</span></p>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>A LIMS' development and use is affected by regulations, standards, and best practices such as:</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>A LIMS' development and use is affected by regulations, standards, and best practices such as:</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>*[[21 CFR Part 11]] ''Electronic records; Electronic signature'': Regulated clinical-focused industries, such as [[medical device]]s or pharmaceuticals, are expected to comply with U.S. [[Food and Drug Administration]] (FDA) regulations like 21 CFR Part 11, which address matters of software validation, data integrity, [[data retention]], audit trails, signed records, and secured access to data. These matters pertain to software systems like LIMS and ELN, as well as <del style="font-weight: bold; text-decoration: none;">otheremployed </del>in modern laboratories.<ref name="21CFR11">{{cite web |url=https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?CFRPart=11&showFR=1 |title=CFR - Code of Federal Regulations Title 21, Part 11 Electronic Records; Electronic Signatures |publisher=U.S. Food and Drug Administration |date=22 December 2023 |accessdate=12 March 2024}}</ref><ref name="RDEditorsAQuick12">{{cite web |url=https://www.rdworldonline.com/a-quick-guide-to-eln-regulatory-requirements/ |title=A Quick Guide to ELN Regulatory Requirements |author=R&D Editors |work=R&D World |date=10 May 2012 |accessdate=12 March 2024}}</ref><ref name="LFWhite20">{{cite web |url=https://labfolder.com/wp-content/uploads/2020/01/Labfolder-CFR21-Part11-Whitepaper.docx-2.pdf |format=PDF |title=Whitepaper: FDA's 21 CFR Part 11 |publisher=Labforward GmbH |date=January 2020 |accessdate=12 March 2024}}</ref></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>*[[21 CFR Part 11]] ''Electronic records; Electronic signature'': Regulated clinical-focused industries, such as [[medical device]]s or pharmaceuticals, are expected to comply with U.S. [[Food and Drug Administration]] (FDA) regulations like 21 CFR Part 11, which address matters of software validation, data integrity, [[data retention]], audit trails, signed records, and secured access to data. These matters pertain to software systems like LIMS and ELN, as well as <ins style="font-weight: bold; text-decoration: none;">other systems employed </ins>in modern laboratories.<ref name="21CFR11">{{cite web |url=https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?CFRPart=11&showFR=1 |title=CFR - Code of Federal Regulations Title 21, Part 11 Electronic Records; Electronic Signatures |publisher=U.S. Food and Drug Administration |date=22 December 2023 |accessdate=12 March 2024}}</ref><ref name="RDEditorsAQuick12">{{cite web |url=https://www.rdworldonline.com/a-quick-guide-to-eln-regulatory-requirements/ |title=A Quick Guide to ELN Regulatory Requirements |author=R&D Editors |work=R&D World |date=10 May 2012 |accessdate=12 March 2024}}</ref><ref name="LFWhite20">{{cite web |url=https://labfolder.com/wp-content/uploads/2020/01/Labfolder-CFR21-Part11-Whitepaper.docx-2.pdf |format=PDF |title=Whitepaper: FDA's 21 CFR Part 11 |publisher=Labforward GmbH |date=January 2020 |accessdate=12 March 2024}}</ref></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*[[ASTM E1578]] ''Standard Guide for Laboratory Informatics'': This standard is geared towards a variety of stakeholders having some sort of professional interest in laboratory informatics. It intends to educate on and recommend approaches to laboratory software development, acquisition, implementation, and maintenance, including as how they relate to LIMS.<ref name="ASTME1578">{{cite web |url=https://www.astm.org/e1578-18.html |title=ASTM E1578-18 Standard Guide for Laboratory Informatics |publisher=ASTM International |date=23 August 2019 |accessdate=13 March 2024}}</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*[[ASTM E1578]] ''Standard Guide for Laboratory Informatics'': This standard is geared towards a variety of stakeholders having some sort of professional interest in laboratory informatics. It intends to educate on and recommend approaches to laboratory software development, acquisition, implementation, and maintenance, including as how they relate to LIMS.<ref name="ASTME1578">{{cite web |url=https://www.astm.org/e1578-18.html |title=ASTM E1578-18 Standard Guide for Laboratory Informatics |publisher=ASTM International |date=23 August 2019 |accessdate=13 March 2024}}</ref></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*[[Good laboratory practice]] (GLP): GLP is a quality- and data-driven approach to ensuring the safety, consistency, high quality, and reliability of developed and produced goods. These best practices address a variety of aspects of non-clinical research and manufacturing laboratory workflows, from personnel and equipment to tests and reporting. Some LIMS are developed to help labs better enforce a GLP approach to its operations.<ref>{{Cite book |date=2023 |editor-last=Elzagheid |editor-first=Mohamed |title=Chemical technicians: good laboratory practice and laboratory information management systems |series=De Gruyter Textbook |edition=1st |publisher=De Gruyter |place=Boston |isbn=978-3-11-119110-2}}</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*[[Good laboratory practice]] (GLP): GLP is a quality- and data-driven approach to ensuring the safety, consistency, high quality, and reliability of developed and produced goods. These best practices address a variety of aspects of non-clinical research and manufacturing laboratory workflows, from personnel and equipment to tests and reporting. Some LIMS are developed to help labs better enforce a GLP approach to its operations.<ref>{{Cite book |date=2023 |editor-last=Elzagheid |editor-first=Mohamed |title=Chemical technicians: good laboratory practice and laboratory information management systems |series=De Gruyter Textbook |edition=1st |publisher=De Gruyter |place=Boston |isbn=978-3-11-119110-2}}</ref></div></td></tr>
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</table>Shawndouglashttps://www.limswiki.org/index.php?title=Laboratory_information_management_system&diff=58761&oldid=prevShawndouglas: /* Regulations, standards, and best practices affecting LIMS development and use */ Spacing2024-03-15T17:00:54Z<p><span dir="auto"><span class="autocomment">Regulations, standards, and best practices affecting LIMS development and use: </span> Spacing</span></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 17:00, 15 March 2024</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*[[ASTM E1578]] ''Standard Guide for Laboratory Informatics'': This standard is geared towards a variety of stakeholders having some sort of professional interest in laboratory informatics. It intends to educate on and recommend approaches to laboratory software development, acquisition, implementation, and maintenance, including as how they relate to LIMS.<ref name="ASTME1578">{{cite web |url=https://www.astm.org/e1578-18.html |title=ASTM E1578-18 Standard Guide for Laboratory Informatics |publisher=ASTM International |date=23 August 2019 |accessdate=13 March 2024}}</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*[[ASTM E1578]] ''Standard Guide for Laboratory Informatics'': This standard is geared towards a variety of stakeholders having some sort of professional interest in laboratory informatics. It intends to educate on and recommend approaches to laboratory software development, acquisition, implementation, and maintenance, including as how they relate to LIMS.<ref name="ASTME1578">{{cite web |url=https://www.astm.org/e1578-18.html |title=ASTM E1578-18 Standard Guide for Laboratory Informatics |publisher=ASTM International |date=23 August 2019 |accessdate=13 March 2024}}</ref></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*[[Good laboratory practice]] (GLP): GLP is a quality- and data-driven approach to ensuring the safety, consistency, high quality, and reliability of developed and produced goods. These best practices address a variety of aspects of non-clinical research and manufacturing laboratory workflows, from personnel and equipment to tests and reporting. Some LIMS are developed to help labs better enforce a GLP approach to its operations.<ref>{{Cite book |date=2023 |editor-last=Elzagheid |editor-first=Mohamed |title=Chemical technicians: good laboratory practice and laboratory information management systems |series=De Gruyter Textbook |edition=1st |publisher=De Gruyter |place=Boston |isbn=978-3-11-119110-2}}</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*[[Good laboratory practice]] (GLP): GLP is a quality- and data-driven approach to ensuring the safety, consistency, high quality, and reliability of developed and produced goods. These best practices address a variety of aspects of non-clinical research and manufacturing laboratory workflows, from personnel and equipment to tests and reporting. Some LIMS are developed to help labs better enforce a GLP approach to its operations.<ref>{{Cite book |date=2023 |editor-last=Elzagheid |editor-first=Mohamed |title=Chemical technicians: good laboratory practice and laboratory information management systems |series=De Gruyter Textbook |edition=1st |publisher=De Gruyter |place=Boston |isbn=978-3-11-119110-2}}</ref></div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*[[ISO 15189]] ''Medical laboratories — Requirements for quality and competence'': This standard specifies quality management approaches to clinical laboratory settings. It pulls inspiration from ISO/IEC 17025 while acknowledging the unique characteristics and needs of the clinical lab. The standard's requirements on laboratory need for addressing cybersecurity, system validation, and more apply directly to LIMS development and implementation.<ref>{{Cite journal |last=Ilinca |first=Radu |last2=Chiriac |first2=Ionuț A. |last3=Luțescu |first3=Dan A. |last4=Ganea |first4=Ionela |last5=Hristodorescu-Grigore |first5=Smaranda |last6=Dănciulescu-Miulescu |first6=Rucsandra-Elena |date=2023-04-01 |title=Understanding the key differences between ISO 15189:2022 and ISO 15189:2012 for an improved medical laboratory quality of service |url=https://www.sciendo.com/article/10.2478/rrlm-2023-0011 |journal=Revista Romana de Medicina de Laborator |language=en |volume=31 |issue=2 |pages=77–82 |doi=10.2478/rrlm-2023-0011 |issn=2284-5623}}</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*[[ISO 15189]] ''Medical laboratories — Requirements for quality and competence'': This standard specifies quality management approaches to clinical laboratory settings. It pulls inspiration from ISO/IEC 17025 while acknowledging the unique characteristics and needs of the clinical lab. The standard's requirements on laboratory need for addressing cybersecurity, system validation, and more apply directly to LIMS development and implementation.<ref>{{Cite journal |last=Ilinca |first=Radu |last2=Chiriac |first2=Ionuț A. |last3=Luțescu |first3=Dan A. |last4=Ganea |first4=Ionela |last5=Hristodorescu-Grigore |first5=Smaranda |last6=Dănciulescu-Miulescu |first6=Rucsandra-Elena |date=2023-04-01 |title=Understanding the key differences between ISO 15189:2022 and ISO 15189:2012 for an improved medical laboratory quality of service |url=https://www.sciendo.com/article/10.2478/rrlm-2023-0011 |journal=Revista Romana de Medicina de Laborator |language=en |volume=31 |issue=2 |pages=77–82 |doi=10.2478/rrlm-2023-0011 |issn=2284-5623}}</ref></div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*[[ISO/IEC 17025]] ''General requirements for the competence of testing and calibration laboratories'': This standard has evolved significantly over the years, today expressing how analytical and calibration labs should best handle quality management through its operations.<ref>{{Cite journal |last=Miguel |first=Anna |last2=Moreira |first2=Renata |last3=Oliveira |first3=André |date=2021 |title=ISO/IEC 17025: History and introduction of concepts |url=http://quimicanova.sbq.org.br/audiencia_pdf.asp?aid2=9279&nomeArquivo=AG2020-0467.pdf |journal=Química Nova |doi=10.21577/0100-4042.20170726}}</ref> Like ISO 15189, this standard addresses many activities of these labs and how they should best performed to conform to a high level of quality. A LIMS has many ways to address the needs of a lab attempting to comply with the standard.<ref name="DouglasWhatKeyISO23" /></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*[[ISO/IEC 17025]] ''General requirements for the competence of testing and calibration laboratories'': This standard has evolved significantly over the years, today expressing how analytical and calibration labs should best handle quality management through its operations.<ref>{{Cite journal |last=Miguel |first=Anna |last2=Moreira |first2=Renata |last3=Oliveira |first3=André |date=2021 |title=ISO/IEC 17025: History and introduction of concepts |url=http://quimicanova.sbq.org.br/audiencia_pdf.asp?aid2=9279&nomeArquivo=AG2020-0467.pdf |journal=Química Nova |doi=10.21577/0100-4042.20170726}}</ref> Like ISO 15189, this standard addresses many activities of these labs and how they should best performed to conform to a high level of quality. A LIMS has many ways to address the needs of a lab attempting to comply with the standard.<ref name="DouglasWhatKeyISO23" /></div></td></tr>
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</table>Shawndouglashttps://www.limswiki.org/index.php?title=Laboratory_information_management_system&diff=58756&oldid=prevShawndouglas: Updated for 20242024-03-13T18:54:06Z<p>Updated for 2024</p>
<a href="https://www.limswiki.org/index.php?title=Laboratory_information_management_system&diff=58756&oldid=57486">Show changes</a>Shawndouglashttps://www.limswiki.org/index.php?title=Laboratory_information_management_system&diff=57486&oldid=prevShawndouglas: Seed-to-sale2023-12-27T22:54:46Z<p>Seed-to-sale</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 22:54, 27 December 2023</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>In addition, a LIMS typically allows for the import and management of raw assay data results.<ref name="LBAssays">{{cite book |title=Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena |author=Khan, Masood N.; Findlay, John W. |chapter=11.6 Integration: Tying It All Together |year=2009 |pages=324 |publisher=John Wiley & Sons |url=https://books.google.com/books?id=QzM0LUMfdAkC |isbn=0470041382 |accessdate=21 March 2020}}</ref> Modern targeted assays such as qPCR and deep [[sequencing]] can produce tens of thousands of data points per sample. Furthermore, in the case of drug and diagnostic development, a dozen or more assays may be run for each sample. In order to track this data, a LIMS solution needs to be adaptable to many different assay formats at both the data layer and import creation layer, while maintaining a high level of overall performance.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>In addition, a LIMS typically allows for the import and management of raw assay data results.<ref name="LBAssays">{{cite book |title=Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena |author=Khan, Masood N.; Findlay, John W. |chapter=11.6 Integration: Tying It All Together |year=2009 |pages=324 |publisher=John Wiley & Sons |url=https://books.google.com/books?id=QzM0LUMfdAkC |isbn=0470041382 |accessdate=21 March 2020}}</ref> Modern targeted assays such as qPCR and deep [[sequencing]] can produce tens of thousands of data points per sample. Furthermore, in the case of drug and diagnostic development, a dozen or more assays may be run for each sample. In order to track this data, a LIMS solution needs to be adaptable to many different assay formats at both the data layer and import creation layer, while maintaining a high level of overall performance.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Increasingly, a LIMS also provides the ability to integrate with third-party applications such as [[enterprise resource planning]] systems or regulatory compliance systems (such as [[<del style="font-weight: bold; text-decoration: none;">cannaqawiki:</del>Seed-to-sale|seed-to-sale]] reporting systems for [[wikipedia:Cannabis|cannabis]] testing).<ref name="CSols10Ways17">{{cite web |url=https://www.csolsinc.com/blog/10-ways-lims-can-automate-lab/ |title=10 Ways LIMS Can Automate Your Lab |publisher=CSols, Inc |date=09 February 2017 |accessdate=13 March 2020}}</ref><ref name="AudinoManaging18">{{cite web |url=https://cannabisindustryjournal.com/feature_article/managing-cannabis-testing-lab-workflows-using-lims/ |title=Managing Cannabis Testing Lab Workflows using LIMS |author=Audino, S. |work=Cannabis Industry Journal |date=07 February 2018 |accessdate=13 March 2019}}</ref> This integration is typically achieved through the use of an [[application programming interface]] (API)<ref name="CSols10Ways17" /><ref name="AudinoManaging18" />, code which serves as an interface between different software programs and facilitates their interaction.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Increasingly, a LIMS also provides the ability to integrate with third-party applications such as [[enterprise resource planning]] systems or regulatory compliance systems (such as [[Seed-to-sale|seed-to-sale]] reporting systems for [[wikipedia:Cannabis|cannabis]] testing).<ref name="CSols10Ways17">{{cite web |url=https://www.csolsinc.com/blog/10-ways-lims-can-automate-lab/ |title=10 Ways LIMS Can Automate Your Lab |publisher=CSols, Inc |date=09 February 2017 |accessdate=13 March 2020}}</ref><ref name="AudinoManaging18">{{cite web |url=https://cannabisindustryjournal.com/feature_article/managing-cannabis-testing-lab-workflows-using-lims/ |title=Managing Cannabis Testing Lab Workflows using LIMS |author=Audino, S. |work=Cannabis Industry Journal |date=07 February 2018 |accessdate=13 March 2019}}</ref> This integration is typically achieved through the use of an [[application programming interface]] (API)<ref name="CSols10Ways17" /><ref name="AudinoManaging18" />, code which serves as an interface between different software programs and facilitates their interaction.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>====Electronic data exchange====</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>====Electronic data exchange====</div></td></tr>
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</table>Shawndouglashttps://www.limswiki.org/index.php?title=Laboratory_information_management_system&diff=45426&oldid=prevShawndouglas: Updated URLs for 20222022-01-06T22:13:03Z<p>Updated URLs for 2022</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 22:13, 6 January 2022</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>====Additional functions====</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>====Additional functions====</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Aside from the key functions of sample management, instrument and application integration, and electronic data exchange, there are numerous additional operations that can be managed in a LIMS. This includes but is not limited to<ref name="ASTM_E1578">{{cite web |url=https://www.astm.org/<del style="font-weight: bold; text-decoration: none;">Standards/E1578</del>.<del style="font-weight: bold; text-decoration: none;">htm </del>|title=ASTM E1578 - 18 Standard Guide for Laboratory Informatics |publisher=ASTM International |accessdate=<del style="font-weight: bold; text-decoration: none;">21 March 2020</del>}}</ref><ref name="TennenhouseHowOur16">{{cite web |url=https://www.labmanager.com/surveys/how-our-readers-are-using-lims-4171 |title=2016 LIMS User Survey Results |author=Tennenhouse, E. |work=Lab Manager |publisher=LabX Media Group |date=22 December 2016 |accessdate=21 March 2020}}</ref><ref name="Barrington-LightDataInt17">{{cite web |url=https://www.biosciencetechnology.com/article/2017/07/data-integrity-challenges-pharmaceutical-manufacturing-meeting-tomorrows-guidelines-today |archiveurl=https://web.archive.org/web/20170914180035/https://www.biosciencetechnology.com/article/2017/07/data-integrity-challenges-pharmaceutical-manufacturing-meeting-tomorrows-guidelines-today |title=Data Integrity Challenges in Pharmaceutical Manufacturing: Meeting Tomorrow’s Guidelines Today |author=Barrington–Light, D. |work=Bioscience Technology |publisher=Advantage Business Media |date=31 July 2017 |archivedate=14 September 2017 |accessdate=21 March 2020}}</ref>:</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Aside from the key functions of sample management, instrument and application integration, and electronic data exchange, there are numerous additional operations that can be managed in a LIMS. This includes but is not limited to<ref name="ASTM_E1578">{{cite web |url=https://www.astm.org/<ins style="font-weight: bold; text-decoration: none;">e1578-18</ins>.<ins style="font-weight: bold; text-decoration: none;">html </ins>|title=ASTM E1578-18 Standard Guide for Laboratory Informatics |publisher=ASTM International |accessdate=<ins style="font-weight: bold; text-decoration: none;">06 January 2022</ins>}}</ref><ref name="TennenhouseHowOur16">{{cite web |url=https://www.labmanager.com/surveys/how-our-readers-are-using-lims-4171 |title=2016 LIMS User Survey Results |author=Tennenhouse, E. |work=Lab Manager |publisher=LabX Media Group |date=22 December 2016 |accessdate=21 March 2020}}</ref><ref name="Barrington-LightDataInt17">{{cite web |url=https://www.biosciencetechnology.com/article/2017/07/data-integrity-challenges-pharmaceutical-manufacturing-meeting-tomorrows-guidelines-today |archiveurl=https://web.archive.org/web/20170914180035/https://www.biosciencetechnology.com/article/2017/07/data-integrity-challenges-pharmaceutical-manufacturing-meeting-tomorrows-guidelines-today |title=Data Integrity Challenges in Pharmaceutical Manufacturing: Meeting Tomorrow’s Guidelines Today |author=Barrington–Light, D. |work=Bioscience Technology |publisher=Advantage Business Media |date=31 July 2017 |archivedate=14 September 2017 |accessdate=21 March 2020}}</ref>:</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>; [[Audit|audit]] management</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>; [[Audit|audit]] management</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>=== LIMS configurability ===</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>=== LIMS configurability ===</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>LIMS implementations are notorious for often being lengthy and costly.<ref name="SciCompRisksBens">{{cite web |url=https://www.scientificcomputing.com/article/2010/03/industry-insights-examining-risks-benefits-and-trade-offs-today%E2%80%99s-lims |title=Industry Insights: Examining the Risks, Benefits and Trade-offs of Today’s LIMS |author=Royce, J.R. |work=Scientific Computing |publisher=Advantage Business Media |date=31 March 2010 |accessdate=14 September 2017}}</ref> This is due in part to the diversity of requirements within each lab, but also to the inflexible nature of LIMS products for adapting to these widely varying requirements. The technology of LIMS solutions has improved as software design methodologies have improved, however, and many more configurable and adaptable options exist than previously. This means not only that implementations are much faster, but also that the costs are lower and the risk of obsolescence is minimized.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>LIMS implementations are notorious for often being lengthy and costly.<ref name="SciCompRisksBens">{{cite web |url=https://www.scientificcomputing.com/article/2010/03/industry-insights-examining-risks-benefits-and-trade-offs-today%E2%80%99s-lims |title=Industry Insights: Examining the Risks, Benefits and Trade-offs of Today’s LIMS |author=Royce, J.R. |work=Scientific Computing |publisher=Advantage Business Media |date=31 March 2010 |accessdate=14 September 2017}}</ref><ins style="font-weight: bold; text-decoration: none;">{{Dead link}} </ins>This is due in part to the diversity of requirements within each lab, but also to the inflexible nature of LIMS products for adapting to these widely varying requirements. The technology of LIMS solutions has improved as software design methodologies have improved, however, and many more configurable and adaptable options exist than previously. This means not only that implementations are much faster, but also that the costs are lower and the risk of obsolescence is minimized.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==The distinction between a LIMS and a LIS==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==The distinction between a LIMS and a LIS==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Historically, the LIMS and LIS have exhibited a few key differences, making them noticeably separate entities<ref name="StarlimsLimsLis">{{cite web |url=http://www.starlims.com/en-us/services-and-resources/resources/lis-vs-lims/ |archiveurl=https://web.archive.org/web/20140428060811/http://www.starlims.com/en-us/resources/white-papers/lis-vs-lims/ |title=Adding "Management" to Your LIS |publisher=STARLIMS Corporation |date=2012 |archivedate=28 April 2014 |accessdate=14 September 2017}}</ref>:</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Historically, the LIMS and LIS have exhibited a few key differences, making them noticeably separate entities<ref name="StarlimsLimsLis">{{cite web |url=http://www.starlims.com/en-us/services-and-resources/resources/lis-vs-lims/ |archiveurl=https://web.archive.org/web/20140428060811/http://www.starlims.com/en-us/resources/white-papers/lis-vs-lims/ |title=Adding "Management" to Your LIS |publisher=STARLIMS Corporation |date=2012 |archivedate=28 April 2014 |accessdate=14 September 2017}}</ref>:</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>1. A LIMS traditionally has been designed to process and report data related to batches of samples from biology labs, water treatment facilities, drug trials, and other entities that handle complex batches of data. A LIS has been designed primarily for processing and reporting data related to individual patients in a clinical setting.<ref name="lislims1">{{cite web |url=http://labsoftnews.typepad.com/lab_soft_news/2008/11/liss-vs-limss-its-time-to-consider-merging-the-two-types-of-systems.html |title=LIS vs. LIMS: It's Time to Blend the Two Types of Lab Information Systems |author=Friedman, B. |work=Lab Soft News |date=04 November 2008 |accessdate=07 November 2012}}</ref><ref name="analytica">{{cite web |url=<del style="font-weight: bold; text-decoration: none;">http</del>://www.analytica-world.com/en/news/35566/lims-lis-market-and-poct-supplement.html |title=LIMS/LIS Market and POCT Supplement |work=analytica-world.com |date=20 February 2004 |accessdate=<del style="font-weight: bold; text-decoration: none;">07 November 2012</del>}}</ref></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>1. A LIMS traditionally has been designed to process and report data related to batches of samples from biology labs, water treatment facilities, drug trials, and other entities that handle complex batches of data. A LIS has been designed primarily for processing and reporting data related to individual patients in a clinical setting.<ref name="lislims1">{{cite web |url=http://labsoftnews.typepad.com/lab_soft_news/2008/11/liss-vs-limss-its-time-to-consider-merging-the-two-types-of-systems.html |title=LIS vs. LIMS: It's Time to Blend the Two Types of Lab Information Systems |author=Friedman, B. |work=Lab Soft News |date=04 November 2008 |accessdate=07 November 2012}}</ref><ref name="analytica">{{cite web |url=<ins style="font-weight: bold; text-decoration: none;">https</ins>://www.analytica-world.com/en/news/35566/lims-lis-market-and-poct-supplement.html |title=LIMS/LIS Market and POCT Supplement |work=analytica-world.com |date=20 February 2004 |accessdate=<ins style="font-weight: bold; text-decoration: none;">06 January 2022</ins>}}</ref></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>2. A LIMS needs to satisfy good manufacturing practice (GMP) and meet the reporting and audit needs of the U.S. [[Food and Drug Administration]] and research scientists in many different industries. A LIS, however, must satisfy the reporting and auditing needs of [[hospital]] accreditation agencies, [[HIPAA]], and other clinical medical practitioners.<ref name="lislims1" /></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>2. A LIMS needs to satisfy good manufacturing practice (GMP) and meet the reporting and audit needs of the U.S. [[Food and Drug Administration]] and research scientists in many different industries. A LIS, however, must satisfy the reporting and auditing needs of [[hospital]] accreditation agencies, [[HIPAA]], and other clinical medical practitioners.<ref name="lislims1" /></div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>3. A LIMS is most competitive in group-centric settings (dealing with "batches" and "samples") that often deal with mostly anonymous research-specific laboratory data, whereas a LIS is usually most competitive in patient-centric settings (dealing with "subjects" and "specimens") and clinical labs.<ref name="analytica" /><ref name="lislims2">{{cite web |url=http://labsoftnews.typepad.com/lab_soft_news/2008/11/lis-vs-lims.html |title=LIS vs. LIMS: Some New Insights |author=Friedman, B. |work=Lab Soft News |date=19 November 2008 |accessdate=07 November 2012}}</ref><ref name="starlims">{{cite web |url=http://blog.starlims.com/2009/07/01/swimming-in-the-clinical-pool-why-lims-are-supplanting-old-school-clinical-lis-applications/ |archiveurl=https://web.archive.org/web/20110313145726/http://blog.starlims.com/2009/07/01/swimming-in-the-clinical-pool-why-lims-are-supplanting-old-school-clinical-lis-applications/ |title=Swimming in the Clinical Pool: Why LIMS are supplanting old-school clinical LIS applications |author=Hice, R. |publisher=STARLIMS Corporation |date=01 July 2009 |archivedate=13 March 2011 |accessdate=14 September 2017}}</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>3. A LIMS is most competitive in group-centric settings (dealing with "batches" and "samples") that often deal with mostly anonymous research-specific laboratory data, whereas a LIS is usually most competitive in patient-centric settings (dealing with "subjects" and "specimens") and clinical labs.<ref name="analytica" /><ref name="lislims2">{{cite web |url=http://labsoftnews.typepad.com/lab_soft_news/2008/11/lis-vs-lims.html |title=LIS vs. LIMS: Some New Insights |author=Friedman, B. |work=Lab Soft News |date=19 November 2008 |accessdate=07 November 2012}}</ref><ref name="starlims">{{cite web |url=http://blog.starlims.com/2009/07/01/swimming-in-the-clinical-pool-why-lims-are-supplanting-old-school-clinical-lis-applications/ |archiveurl=https://web.archive.org/web/20110313145726/http://blog.starlims.com/2009/07/01/swimming-in-the-clinical-pool-why-lims-are-supplanting-old-school-clinical-lis-applications/ |title=Swimming in the Clinical Pool: Why LIMS are supplanting old-school clinical LIS applications |author=Hice, R. |publisher=STARLIMS Corporation |date=01 July 2009 |archivedate=13 March 2011 |accessdate=14 September 2017}}</ref></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>However, these distinctions began to fade somewhat in the early 2010s as some LIMS vendors began to adopt the case-centric information management normally reserved for a LIS, blurring the lines between the two components further.<ref name="starlims" /> [[Thermo Scientific]]'s Clinical LIMS was an example of this merger of LIMS with LIS, with Dave Champagne, informatics vice president and general manager, stating: "Routine molecular diagnostics requires a convergence of the up-to-now separate systems that have managed work in the lab (the LIMS) and the clinic (the LIS). The industry is asking for, and the science is requiring, a single lab-centric solution that delivers patient-centric results."<ref name="ConvergeLimsLis">{{cite web |url=<del style="font-weight: bold; text-decoration: none;">http</del>://<del style="font-weight: bold; text-decoration: none;">www.</del>clpmag.com/<del style="font-weight: bold; text-decoration: none;">2012</del>/<del style="font-weight: bold; text-decoration: none;">02</del>/convergence-of-lims-and-lis/ |title=Convergence of LIMS and LIS |author=Tufel, G. |work=Clinical Lab Products |publisher=MEDQOR |date=01 February 2012 |accessdate=<del style="font-weight: bold; text-decoration: none;">14 September 2017</del>}}</ref> [[Abbott Informatics Corporation]]'s STARLIMS product was another example of this LIMS/LIS merger.<ref name="StarlimsLimsLis" /> With the distinction between the two entities becoming less clear, discussions within the laboratory informatics community began to includes the question of whether or not the two entities should be considered the same.<ref name="LinkedInDifLisLims">{{cite web |url=https://www.linkedin.com/feed/update/urn:li:groupPost:2069898-98494737/ |title=What is the difference between a LIS and a LIMS? |author=Jones, J. |publisher=LinkedIn |date=March 2012 |accessdate=14 September 2017}}</ref><ref name="LinkedInLisLimsSame">{{cite web |url=http://www.linkedin.com/groups/Are-LIMS-LIS-same-thing-2069898.S.147132083 |title=Are LIMS and LIS the same thing? |author=Jones, John |publisher=LinkedIn |date=September 2012 |accessdate=07 November 2012}}</ref> {{As of|2017}}, vendors continue to recognize the historical differences between the two products while also continuing to acknowledge that some developed LIMS are taking on more of the clinical aspects usually reserved for a LIS.<ref name="AgilabFAQ">{{cite web |url=http://agilab.com/faq/ |archiveurl=https://web.archive.org/web/20190325075813/http://agilab.com/faq/ |title=FAQ: What is the difference between a LIMS and a medical laboratory quality system? |publisher=AgiLab SAS |archivedate=25 March 2019 |accessdate=21 March 2020}}</ref><ref name="CloudLISDifference16">{{cite web |url=https://cloudlims.com/lims/lims-vs-lis.html |title=Difference Between LIS and LIMS |publisher=CloudLIMS.com, LLC |date=01 October 2016 |accessdate=14 September 2017}}</ref><ref name="ReisenwitzWhatIs17">{{cite web |url=<del style="font-weight: bold; text-decoration: none;">http</del>://blog.capterra.com/what-is-a-laboratory-information-management-system/ |title=What Is a Laboratory Information Management System? |author=Reisenwitz, C. |work=Capterra Medical Software Blog |publisher=Capterra, Inc |date=11 May 2017 |accessdate=<del style="font-weight: bold; text-decoration: none;">14 September 2017</del>}}</ref></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>However, these distinctions began to fade somewhat in the early 2010s as some LIMS vendors began to adopt the case-centric information management normally reserved for a LIS, blurring the lines between the two components further.<ref name="starlims" /> [[Thermo Scientific]]'s Clinical LIMS was an example of this merger of LIMS with LIS, with Dave Champagne, informatics vice president and general manager, stating: "Routine molecular diagnostics requires a convergence of the up-to-now separate systems that have managed work in the lab (the LIMS) and the clinic (the LIS). The industry is asking for, and the science is requiring, a single lab-centric solution that delivers patient-centric results."<ref name="ConvergeLimsLis">{{cite web |url=<ins style="font-weight: bold; text-decoration: none;">https</ins>://clpmag.com/<ins style="font-weight: bold; text-decoration: none;">lab-essentials</ins>/<ins style="font-weight: bold; text-decoration: none;">information-technology</ins>/convergence-of-lims-and-lis/ |title=Convergence of LIMS and LIS |author=Tufel, G. |work=Clinical Lab Products |publisher=MEDQOR |date=01 February 2012 |accessdate=<ins style="font-weight: bold; text-decoration: none;">06 January 2022</ins>}}</ref> [[Abbott Informatics Corporation]]'s STARLIMS product was another example of this LIMS/LIS merger.<ref name="StarlimsLimsLis" /> With the distinction between the two entities becoming less clear, discussions within the laboratory informatics community began to includes the question of whether or not the two entities should be considered the same.<ref name="LinkedInDifLisLims">{{cite web |url=https://www.linkedin.com/feed/update/urn:li:groupPost:2069898-98494737/ |title=What is the difference between a LIS and a LIMS? |author=Jones, J. |publisher=LinkedIn |date=March 2012 |accessdate=14 September 2017}}</ref><ref name="LinkedInLisLimsSame">{{cite web |url=http://www.linkedin.com/groups/Are-LIMS-LIS-same-thing-2069898.S.147132083 |title=Are LIMS and LIS the same thing? |author=Jones, John |publisher=LinkedIn |date=September 2012 |accessdate=07 November 2012}}</ref> {{As of|2017}}, vendors continue to recognize the historical differences between the two products while also continuing to acknowledge that some developed LIMS are taking on more of the clinical aspects usually reserved for a LIS.<ref name="AgilabFAQ">{{cite web |url=http://agilab.com/faq/ |archiveurl=https://web.archive.org/web/20190325075813/http://agilab.com/faq/ |title=FAQ: What is the difference between a LIMS and a medical laboratory quality system? |publisher=AgiLab SAS |archivedate=25 March 2019 |accessdate=21 March 2020}}</ref><ref name="CloudLISDifference16">{{cite web |url=https://cloudlims.com/lims/lims-vs-lis.html |title=Difference Between LIS and LIMS |publisher=CloudLIMS.com, LLC |date=01 October 2016 |accessdate=14 September 2017}}</ref><ref name="ReisenwitzWhatIs17">{{cite web |url=<ins style="font-weight: bold; text-decoration: none;">https</ins>://blog.capterra.com/what-is-a-laboratory-information-management-system/ |title=What Is a Laboratory Information Management System? |author=Reisenwitz, C. |work=Capterra Medical Software Blog |publisher=Capterra, Inc |date=11 May 2017 |accessdate=<ins style="font-weight: bold; text-decoration: none;">06 January 2022</ins>}}</ref></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Standards affecting LIMS==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Standards affecting LIMS==</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Further reading==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Further reading==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* {{cite journal |title=A brief history of LIMS |journal=Laboratory Automation and Information Management|author=Gibbon, G.A. |volume=32 |issue=1 |pages=1–5 |year=1996 |doi=10.1016/1381-141X(95)00024-K}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* {{cite journal |title=A brief history of LIMS |journal=Laboratory Automation and Information Management|author=Gibbon, G.A. |volume=32 |issue=1 |pages=1–5 |year=1996 |doi=10.1016/1381-141X(95)00024-K}}</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* {{cite web |url=https://www.it.uu.se/edu/course/homepage/lims/vt12/ComprehensiveLaboratoryInformatics.pdf |archiveurl=https://web.archive.org/web/20170825181932/https://www.it.uu.se/edu/course/homepage/lims/vt12/ComprehensiveLaboratoryInformatics.pdf |format=PDF |title=Comprehensive Laboratory Informatics: A Multilayer Approach |author=Wood, S. |work=American Laboratory |page=1 |date=September 2007 |archivedate=25 August 2017}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* {{cite web |url=https://www.it.uu.se/edu/course/homepage/lims/vt12/ComprehensiveLaboratoryInformatics.pdf |archiveurl=https://web.archive.org/web/20170825181932/https://www.it.uu.se/edu/course/homepage/lims/vt12/ComprehensiveLaboratoryInformatics.pdf |format=PDF |title=Comprehensive Laboratory Informatics: A Multilayer Approach |author=Wood, S. |work=American Laboratory |page=1 |date=September 2007 |archivedate=25 August 2017}}</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==References==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==References==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Reflist|colwidth=30em}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Reflist|colwidth=30em}}</div></td></tr>
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</table>Shawndouglashttps://www.limswiki.org/index.php?title=Laboratory_information_management_system&diff=38687&oldid=prevShawndouglas: More minor updates for 20202020-03-21T21:29:50Z<p>More minor updates for 2020</p>
<a href="https://www.limswiki.org/index.php?title=Laboratory_information_management_system&diff=38687&oldid=38629">Show changes</a>Shawndouglashttps://www.limswiki.org/index.php?title=Laboratory_information_management_system&diff=38629&oldid=prevShawndouglas: /* Instrument and application integration */ Added software integration2020-03-13T20:15:34Z<p><span dir="auto"><span class="autocomment">Instrument and application integration: </span> Added software integration</span></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 20:15, 13 March 2020</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>====Instrument and application integration====</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>====Instrument and application integration====</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Modern LIMS offer integration with laboratory instruments <del style="font-weight: bold; text-decoration: none;">and applications </del>as standard. A LIMS may create control files that are "fed" into the instrument and direct its operation on some physical item such as a sample tube or sample plate. The LIMS may then import instrument results files to extract data for quality control assessment of the operation on the sample. Access to the instrument data can sometimes be regulated based on chain of custody assignments or other security features if need be.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Modern LIMS offer integration with laboratory instruments as standard. A LIMS may create control files that are "fed" into the instrument and direct its operation on some physical item such as a sample tube or sample plate. The LIMS may then import instrument results files to extract data for quality control assessment of the operation on the sample. Access to the instrument data can sometimes be regulated based on chain of custody assignments or other security features if need be.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>LIMS additionally typically allow for the import and management of raw assay data results.<ref name="LBAssays">{{cite book |title=Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena |author=Khan, Masood N.; Findlay, John W. |chapter=11.6 Integration: Tying It All Together |year=2009 |pages=324 |publisher=John Wiley & Sons |url=http://books.google.com/books?id=QzM0LUMfdAkC |isbn=0470041382 |accessdate=07 November 2012}}</ref> Modern targeted assays such as qPCR and deep [[sequencing]] can produce tens of thousands of data points per sample. Furthermore, in the case of drug and diagnostic development, as many as 12 or more assays may be run for each sample. In order to track this data, a LIMS solution needs to be adaptable to many different assay formats at both the data layer and import creation layer, while maintaining a high level of overall performance.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>LIMS additionally typically allow for the import and management of raw assay data results.<ref name="LBAssays">{{cite book |title=Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena |author=Khan, Masood N.; Findlay, John W. |chapter=11.6 Integration: Tying It All Together |year=2009 |pages=324 |publisher=John Wiley & Sons |url=http://books.google.com/books?id=QzM0LUMfdAkC |isbn=0470041382 |accessdate=07 November 2012}}</ref> Modern targeted assays such as qPCR and deep [[sequencing]] can produce tens of thousands of data points per sample. Furthermore, in the case of drug and diagnostic development, as many as 12 or more assays may be run for each sample. In order to track this data, a LIMS solution needs to be adaptable to many different assay formats at both the data layer and import creation layer, while maintaining a high level of overall performance.</div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Increasingly, LIMS also provide the ability to integrate with third-party applications such as [[enterprise resource planning]] systems or regulatory compliance systems (such as [[cannaqawiki:Seed-to-sale|seed-to-sale]] reporting systems for [[wikipedia:Cannabis|cannabis]] testing).<ref name="CSols10Ways17">{{cite web |url=https://www.csolsinc.com/blog/10-ways-lims-can-automate-lab/ |title=10 Ways LIMS Can Automate Your Lab |publisher=CSols, Inc |date=09 February 2017 |accessdate=13 March 2020}}</ref><ref name="AudinoManaging18">{{cite web |url=https://cannabisindustryjournal.com/feature_article/managing-cannabis-testing-lab-workflows-using-lims/ |title=Managing Cannabis Testing Lab Workflows using LIMS |author=Audino, S. |work=Cannabis Industry Journal |date=07 February 2018 |accessdate=13 March 2019}}</ref> This integration is typically achieved through the use of an [[application programming interface]] (API)<ref name="CSols10Ways17" /><ref name="AudinoManaging18" />, code which serves as an interface between different software programs and facilitates their interaction.</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>====Electronic data exchange====</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>====Electronic data exchange====</div></td></tr>
</table>Shawndouglashttps://www.limswiki.org/index.php?title=Laboratory_information_management_system&diff=38628&oldid=prevShawndouglas: /* History of LIMS */2020-03-13T19:24:11Z<p><span dir="auto"><span class="autocomment">History of LIMS</span></span></p>
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</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l15">Line 15:</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>By 1995, the client/server tools had developed to the point of allowing processing of data anywhere on the network. Web-enabled LIMS were introduced the following year, enabling researchers to extend operations outside the confines of the laboratory. From 1996 to 2002 additional functionality was included in LIMS, from wireless networking capabilities and georeferencing of samples, to the adoption of [[XML]] standards and the development of internet purchasing.<ref name="LIMSHistory" /></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>By 1995, the client/server tools had developed to the point of allowing processing of data anywhere on the network. Web-enabled LIMS were introduced the following year, enabling researchers to extend operations outside the confines of the laboratory. From 1996 to 2002 additional functionality was included in LIMS, from wireless networking capabilities and georeferencing of samples, to the adoption of [[XML]] standards and the development of internet purchasing.<ref name="LIMSHistory" /></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>By the early 2010s, some LIMS had added additional characteristics that continued to shape how a LIMS was defined. Examples included the addition of clinical functionality and [[electronic laboratory notebook]] (ELN) functionality, as well a rise in the cloud-based [[software as a service]] (SaaS) distribution model.<ref name="LinkedInSaaSModel">{{cite web |url=https://www.linkedin.com/groups/2069898/2069898-181604484 |title=Is any one aware of a SaaS LIMS success story? |author=Nagisetty, P. |publisher=LinkedIn |date=02 November 2012 |accessdate=14 September 2017}}</ref><ref name="MullinLIMS10">{{cite journal |title=LIMS in the Cloud |journal=Chemical & Engineering News |author=Mullin, R. |volume=88 |issue=21 |pages=12–16 |date=24 May 2010 |url=http://cen.acs.org/articles/88/i21/LIMS-Cloud.html |accessdate=14 September 2017}}</ref> <del style="font-weight: bold; text-decoration: none;">{{As of|</del>2017<del style="font-weight: bold; text-decoration: none;">}}</del>, cloud-based LIMS <del style="font-weight: bold; text-decoration: none;">are </del>more numerous in quantity and adoption but not the de facto standard, as the costs and daunting nature associated with vendors transitioning legacy products to the cloud and with companies trying to integrate a cloud-based LIMS into a complicated IT environment have partially stymied growth.<ref name="KnippenbergMoving17">{{cite web |url=http://astrixinc.com/moving-lab-infrastructure-cloud-consider-nearshoring/ |title=Moving your Lab IT Infrastructure to the Cloud? Consider Nearshoring |author=Knippenberg, R. |work=Astrix Blog |publisher=Astrix Technology Group |date=09 May 2017 |accessdate=14 September 2017}}</ref><ref name="JoyceWhatYou17">{{cite web |url=http://www.labmanager.com/business-management/2017/04/what-you-and-your-it-team-should-know-about-the-cloud |title=What You and Your IT Team Should Know About the Cloud |work=Lab Manager |author=Joyce, J. |publisher=LabX Media Group |date=01 May 2017 |accessdate=14 September 2017}}</ref></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>By the early 2010s, some LIMS had added additional characteristics that continued to shape how a LIMS was defined. Examples included the addition of clinical functionality and [[electronic laboratory notebook]] (ELN) functionality, as well a rise in the cloud-based [[software as a service]] (SaaS) distribution model.<ref name="LinkedInSaaSModel">{{cite web |url=https://www.linkedin.com/groups/2069898/2069898-181604484 |title=Is any one aware of a SaaS LIMS success story? |author=Nagisetty, P. |publisher=LinkedIn |date=02 November 2012 |accessdate=14 September 2017}}</ref><ref name="MullinLIMS10">{{cite journal |title=LIMS in the Cloud |journal=Chemical & Engineering News |author=Mullin, R. |volume=88 |issue=21 |pages=12–16 |date=24 May 2010 |url=http://cen.acs.org/articles/88/i21/LIMS-Cloud.html |accessdate=14 September 2017}}</ref> <ins style="font-weight: bold; text-decoration: none;">By late </ins>2017, cloud-based LIMS <ins style="font-weight: bold; text-decoration: none;">were </ins>more numerous in quantity and adoption but not the de facto standard, as the costs and daunting nature associated with vendors transitioning legacy products to the cloud and with companies trying to integrate a cloud-based LIMS into a complicated IT environment have partially stymied growth.<ref name="KnippenbergMoving17">{{cite web |url=http://astrixinc.com/moving-lab-infrastructure-cloud-consider-nearshoring/ |title=Moving your Lab IT Infrastructure to the Cloud? Consider Nearshoring |author=Knippenberg, R. |work=Astrix Blog |publisher=Astrix Technology Group |date=09 May 2017 |accessdate=14 September 2017}}</ref><ref name="JoyceWhatYou17">{{cite web |url=http://www.labmanager.com/business-management/2017/04/what-you-and-your-it-team-should-know-about-the-cloud |title=What You and Your IT Team Should Know About the Cloud |work=Lab Manager |author=Joyce, J. |publisher=LabX Media Group |date=01 May 2017 |accessdate=14 September 2017<ins style="font-weight: bold; text-decoration: none;">}}</ref> Despite these challenges, market research companies such as Markets and Markets believe that cloud-based version of the LIMS will see the highest growth rate in the coming years, citing "on-demand self-serving analytics, ease of use, affordability, reliability, no upfront capital investment for hardware, adaptability & flexibility, and a pay-as-you-go pricing model" as primary drivers.<ref name="MMLab18">{{cite web |url=https://www.marketsandmarkets.com/Market-Reports/laboratory-information-management-systems-market-250610373.html |title=Laboratory Information Management System Market by Type (Broad), Component (Software, Service), Deployment Model (On-premise, Remote, Cloud), Industry (CRO, CMO, Toxicology, Pharma, Biotech, Chemical, Agriculture, Oil, Gas) - Global Forecast to 2023 |author=Markets and Markets |publisher=MarketsandMarkets Research Private Ltd |date=July 2018 |accessdate=13 March 2020</ins>}}</ref></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Technology==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Technology==</div></td></tr>
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</table>Shawndouglas