Difference between revisions of "Template:Article of the week"

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(Updated article of the week text.)
(Updated article of the week text.)
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<div style="float: left; margin: 0.5em 0.9em 0.4em 0em;">[[File:Fig1 Goldberg mBio2015 6-6.jpg|240px]]</div>
<div style="float: left; margin: 0.5em 0.9em 0.4em 0em;">[[File:Fig1 Gates JofResearchNIST2015 120.jpg|240px]]</div>
'''"[[Journal:Making the leap from research laboratory to clinic: Challenges and opportunities for next-generation sequencing in infectious disease diagnostics|Making the leap from research laboratory to clinic: Challenges and opportunities for next-generation sequencing in infectious disease diagnostics]]"'''
'''"[[Journal:Smart electronic laboratory notebooks for the NIST research environment|Smart electronic laboratory notebooks for the NIST research environment]]"'''


Next-generation DNA sequencing (NGS) has progressed enormously over the past decade, transforming [[Genomics|genomic]] analysis and opening up many new opportunities for applications in clinical microbiology [[Laboratory|laboratories]]. The impact of NGS on microbiology has been revolutionary, with new microbial genomic sequences being generated daily, leading to the development of large databases of genomes and gene sequences. The ability to analyze microbial communities without culturing organisms has created the ever-growing field of metagenomics and microbiome analysis and has generated significant new insights into the relation between host and microbe. The medical literature contains many examples of how this new technology can be used for infectious disease diagnostics and pathogen analysis. The implementation of NGS in medical practice has been a slow process due to various challenges such as clinical trials, lack of applicable regulatory guidelines, and the adaptation of the technology to the clinical environment. In April 2015, the American Academy of Microbiology (AAM) convened a colloquium to begin to define these issues, and in this document, we present some of the concepts that were generated from these discussions. ('''[[Journal:Making the leap from research laboratory to clinic: Challenges and opportunities for next-generation sequencing in infectious disease diagnostics|Full article...]]''')<br />
[[Laboratory notebook]]s have been a staple of scientific research for centuries for organizing and documenting ideas and experiments. Modern [[Laboratory|laboratories]] are increasingly reliant on electronic data collection and analysis, so it seems inevitable that the digital revolution should come to the ordinary laboratory notebook. The most important aspect of this transition is to make the shift as comfortable and intuitive as possible, so that the creative process that is the hallmark of scientific investigation and engineering achievement is maintained, and ideally enhanced. The smart [[electronic laboratory notebook]]s described in this paper represent a paradigm shift from the old pen and paper style notebooks and provide a host of powerful operational and documentation capabilities in an intuitive format that is available anywhere at any time. ('''[[Journal:Smart electronic laboratory notebooks for the NIST research environment|Full article...]]''')<br />
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''Recently featured'':  
''Recently featured'':  
: ▪ [[Journal:Making the leap from research laboratory to clinic: Challenges and opportunities for next-generation sequencing in infectious disease diagnostics|Making the leap from research laboratory to clinic: Challenges and opportunities for next-generation sequencing in infectious disease diagnostics]]
: ▪ [[Journal:Information technology support for clinical genetic testing within an academic medical center|Information technology support for clinical genetic testing within an academic medical center]]
: ▪ [[Journal:Information technology support for clinical genetic testing within an academic medical center|Information technology support for clinical genetic testing within an academic medical center]]
: ▪ [[Journal:Principles of metadata organization at the ENCODE data coordination center|Principles of metadata organization at the ENCODE data coordination center]]
: ▪ [[Journal:Principles of metadata organization at the ENCODE data coordination center|Principles of metadata organization at the ENCODE data coordination center]]
: ▪ [[Journal:Integrated systems for NGS data management and analysis: Open issues and available solutions|Integrated systems for NGS data management and analysis: Open issues and available solutions]]

Revision as of 16:56, 28 November 2016

Fig1 Gates JofResearchNIST2015 120.jpg

"Smart electronic laboratory notebooks for the NIST research environment"

Laboratory notebooks have been a staple of scientific research for centuries for organizing and documenting ideas and experiments. Modern laboratories are increasingly reliant on electronic data collection and analysis, so it seems inevitable that the digital revolution should come to the ordinary laboratory notebook. The most important aspect of this transition is to make the shift as comfortable and intuitive as possible, so that the creative process that is the hallmark of scientific investigation and engineering achievement is maintained, and ideally enhanced. The smart electronic laboratory notebooks described in this paper represent a paradigm shift from the old pen and paper style notebooks and provide a host of powerful operational and documentation capabilities in an intuitive format that is available anywhere at any time. (Full article...)

Recently featured:

Making the leap from research laboratory to clinic: Challenges and opportunities for next-generation sequencing in infectious disease diagnostics
Information technology support for clinical genetic testing within an academic medical center
Principles of metadata organization at the ENCODE data coordination center