Difference between revisions of "Template:Article of the week"

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(Updated article of the week text.)
(Updated article of the week text.)
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<div style="float: left; margin: 0.5em 0.9em 0.4em 0em;">[[File:Fig1 Clay CancerInformatics2017 16.png|240px]]</div>
<div style="float: left; margin: 0.5em 0.9em 0.4em 0em;">[[File:Fig1 Tsur BioDataMining2017 10.gif|240px]]</div>
'''"[[Journal:Bioinformatics education in pathology training: Current scope and future direction|Bioinformatics education in pathology training: Current scope and future direction]]"'''
'''"[[Journal:Rapid development of entity-based data models for bioinformatics with persistence object-oriented design and structured interfaces|Rapid development of entity-based data models for bioinformatics with persistence object-oriented design and structured interfaces]]"'''


Training [[Anatomical pathology|anatomic]] and [[clinical pathology]] residents in the principles of [[bioinformatics]] is a challenging endeavor. Most residents receive little to no formal exposure to bioinformatics during medical education, and most of the pathology training is spent interpreting [[histopathology]] slides using light microscopy or focused on laboratory regulation, management, and interpretation of discrete [[laboratory]] data. At a minimum, residents should be familiar with data structure, data pipelines, data manipulation, and data regulations within [[Clinical laboratory|clinical laboratories]]. Fellowship-level training should incorporate advanced principles unique to each subspecialty. Barriers to bioinformatics education include the clinical apprenticeship training model, ill-defined educational milestones, inadequate faculty expertise, and limited exposure during medical training. Online educational resources, case-based learning, and incorporation into molecular genomics education could serve as effective educational strategies. Overall, pathology bioinformatics training can be incorporated into pathology resident curricula, provided there is motivation to incorporate institutional support, educational resources, and adequate faculty expertise. ('''[[Journal:Bioinformatics education in pathology training: Current scope and future direction|Full article...]]''')<br />
Databases are imperative for research in [[bioinformatics]] and computational biology. Current challenges in database design include data heterogeneity and context-dependent interconnections between data entities. These challenges drove the development of unified data interfaces and specialized databases. The curation of specialized databases is an ever-growing challenge due to the introduction of new data sources and the emergence of new relational connections between established datasets. Here, an open-source framework for the curation of specialized databases is proposed. The framework supports user-designed models of data encapsulation, object persistence and structured interfaces to local and external data sources such as MalaCards, Biomodels and the National Center for Biotechnology Information (NCBI) databases. The proposed framework was implemented using Java as the development environment, EclipseLink as the data persistence agent and Apache Derby as the database manager. Syntactic analysis was based on J3D, jsoup, Apache Commons and w3c.dom open libraries. Finally, a construction of a specialized database for aneurysm-associated vascular diseases is demonstrated. This database contains three-dimensional geometries of aneurysms, patients' clinical information, articles, biological models, related diseases and our recently published model of aneurysms’ risk of rapture. The framework is available at: http://nbel-lab.com. ('''[[Journal:Rapid development of entity-based data models for bioinformatics with persistence object-oriented design and structured interfaces|Full article...]]''')<br />
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''Recently featured'':  
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Revision as of 16:54, 9 October 2017

Fig1 Tsur BioDataMining2017 10.gif

"Rapid development of entity-based data models for bioinformatics with persistence object-oriented design and structured interfaces"

Databases are imperative for research in bioinformatics and computational biology. Current challenges in database design include data heterogeneity and context-dependent interconnections between data entities. These challenges drove the development of unified data interfaces and specialized databases. The curation of specialized databases is an ever-growing challenge due to the introduction of new data sources and the emergence of new relational connections between established datasets. Here, an open-source framework for the curation of specialized databases is proposed. The framework supports user-designed models of data encapsulation, object persistence and structured interfaces to local and external data sources such as MalaCards, Biomodels and the National Center for Biotechnology Information (NCBI) databases. The proposed framework was implemented using Java as the development environment, EclipseLink as the data persistence agent and Apache Derby as the database manager. Syntactic analysis was based on J3D, jsoup, Apache Commons and w3c.dom open libraries. Finally, a construction of a specialized database for aneurysm-associated vascular diseases is demonstrated. This database contains three-dimensional geometries of aneurysms, patients' clinical information, articles, biological models, related diseases and our recently published model of aneurysms’ risk of rapture. The framework is available at: http://nbel-lab.com. (Full article...)

Recently featured:

Bioinformatics education in pathology training: Current scope and future direction
FluxCTTX: A LIMS-based tool for management and analysis of cytotoxicity assays data
Bioinformatics: Indispensable, yet hidden in plain sight