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'''"[[Journal:Defending our public biological databases as a global critical infrastructure|Defending our public biological databases as a global critical infrastructure]]"'''
'''"[[Journal:Learning health systems need to bridge the "two cultures" of clinical informatics and data science|Learning health systems need to bridge the "two cultures" of clinical informatics and data science]]"'''


United Kingdom (U.K.) health research policy and plans for population health management are predicated upon transformative knowledge discovery from operational "big data." Learning health systems require not only data but also feedback loops of knowledge into changed practice. This depends on [[Information management|knowledge management]] and application, which in turn depends upon effective system design and implementation. [[Health informatics|Biomedical informatics]] is the interdisciplinary field at the intersection of health science, social science, and information science and technology that spans this entire scope.
Progress in modern biology is being driven, in part, by the large amounts of freely available data in public resources such as the International Nucleotide Sequence Database Collaboration (INSDC), the world's primary database of biological sequence (and related) [[information]]. INSDC and similar databases have dramatically increased the pace of fundamental biological discovery and enabled a host of innovative therapeutic, diagnostic, and forensic applications. However, as high-value, openly shared resources with a high degree of assumed trust, these repositories share compelling similarities to the early days of the internet. Consequently, as public biological databases continue to increase in size and importance, we expect that they will face the same threats as undefended cyberspace. There is a unique opportunity, before a significant breach and loss of trust occurs, to ensure they evolve with quality and security as a design philosophy rather than costly “retrofitted” mitigations. This perspective article surveys some potential quality assurance and security weaknesses in existing open [[Genomics|genomic]] and [[Proteomics|proteomic]] repositories, describes methods to mitigate the likelihood of both intentional and unintentional errors, and offers recommendations for risk mitigation based on lessons learned from [[cybersecurity]]. ('''[[Journal:Defending our public biological databases as a global critical infrastructure|Full article...]]''')<br />
 
In the U.K., the separate worlds of health data science ([[bioinformatics]], big data) and effective healthcare system design and implementation ([[Health informatics#Clinical informatics|clinical informatics]], "digital health") have operated as "two cultures." Much National Health Service and social care data is of very poor quality. Substantial research funding is wasted on data cleansing or by producing very weak evidence. There is not yet a sufficiently powerful professional community or evidence base of best practice to influence the practitioner community or the digital health industry. ('''[[Journal:Learning health systems need to bridge the "two cultures" of clinical informatics and data science|Full article...]]''')<br />
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Revision as of 15:16, 23 July 2019

"Defending our public biological databases as a global critical infrastructure"

Progress in modern biology is being driven, in part, by the large amounts of freely available data in public resources such as the International Nucleotide Sequence Database Collaboration (INSDC), the world's primary database of biological sequence (and related) information. INSDC and similar databases have dramatically increased the pace of fundamental biological discovery and enabled a host of innovative therapeutic, diagnostic, and forensic applications. However, as high-value, openly shared resources with a high degree of assumed trust, these repositories share compelling similarities to the early days of the internet. Consequently, as public biological databases continue to increase in size and importance, we expect that they will face the same threats as undefended cyberspace. There is a unique opportunity, before a significant breach and loss of trust occurs, to ensure they evolve with quality and security as a design philosophy rather than costly “retrofitted” mitigations. This perspective article surveys some potential quality assurance and security weaknesses in existing open genomic and proteomic repositories, describes methods to mitigate the likelihood of both intentional and unintentional errors, and offers recommendations for risk mitigation based on lessons learned from cybersecurity. (Full article...)

Recently featured:

▪ Determining the hospital information system (HIS) success rate: Development of a new instrument and case study
▪ Smart information systems in cybersecurity: An ethical analysis
▪ Chemometric analysis of cannabinoids: Chemotaxonomy and domestication syndrome
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