Difference between revisions of "Template:Article of the week"

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'''"[[Journal:Next steps for access to safe, secure DNA synthesis|Next steps for access to safe, secure DNA synthesis]]"'''
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<div style="float: left; margin: 0.5em 0.9em 0.4em 0em;">[[File:Fig1 Baratta FrontPharmaco2019 10.jpg|240px]]</div>
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'''"[[Journal:Development of standard operating protocols for the optimization of Cannabis-based formulations for medical purposes|Development of standard operating protocols for the optimization of Cannabis-based formulations for medical purposes]]"'''
  
The [[DNA synthesis]] industry has, since the invention of gene-length synthesis, worked proactively to ensure synthesis is carried out securely and safely. Informed by guidance from the U.S. government, several of these companies have collaborated over the last decade to produce a set of best practices for customer and sequence screening prior to manufacture. Taken together, these practices ensure that synthetic DNA is used to advance research that is designed and intended for public benefit. With increasing scale in the industry and expanding capability in the synthetic biology toolset, it is worth revisiting current practices to evaluate additional measures to ensure the continued safety and wide availability of DNA synthesis. Here we encourage specific steps, in part derived from successes in the [[cybersecurity]] community, that can ensure synthesis screening systems stay well ahead of emerging challenges, to continue to enable responsible research advances. [[Artificial gene synthesis|Gene synthesis]] companies, science and technology funders, policymakers, and the scientific community as a whole have a shared duty to continue to minimize risk and maximize the safety and security of DNA synthesis to further power world-changing developments in advanced biological manufacturing, agriculture, drug development, healthcare, and energy. ('''[[Journal:Next steps for access to safe, secure DNA synthesis|Full article...]]''')<br />
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Under current legislation in Italy, using the ''[[wikipedia:Cannabis|Cannabis]]'' plant for medical purposes requires administering it orally in the form of a decoction or as ''Cannabis'' oil extract. The scientific literature reports a number of preparation methods, mainly for oils, but no study is available that compares thoroughly, from a technological viewpoint, the ''Cannabis''-based formulations currently administered to patients. With this in mind, this research work aimed to carry out specific formulation studies to design standard operating procedures for the preparation and optimization of ''Cannabis''-based galenic formulations. Both decoctions and oils were prepared under different operating conditions to identify the most efficient process for the production of formulations with a high concentration of [[wikipedia:Decarboxylation|decarboxylated]] [[wikipedia:Tetrahydrocannabinol|delta-9-tetrahydrocannabinol]] (THC) and [[wikipedia:Cannabidiol|cannabidiol]] (CBD). Regarding ''Cannabis'' oil, a new procedure has been developed that allows significantly higher recovery rates for THC and CBD compared with those for water-based extraction methods (decoction) and those for oil-based methods currently in use. ('''[[Journal:Development of standard operating protocols for the optimization of Cannabis-based formulations for medical purposes|Full article...]]''')<br />
 
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Revision as of 16:37, 23 September 2019

Fig1 Baratta FrontPharmaco2019 10.jpg

"Development of standard operating protocols for the optimization of Cannabis-based formulations for medical purposes"

Under current legislation in Italy, using the Cannabis plant for medical purposes requires administering it orally in the form of a decoction or as Cannabis oil extract. The scientific literature reports a number of preparation methods, mainly for oils, but no study is available that compares thoroughly, from a technological viewpoint, the Cannabis-based formulations currently administered to patients. With this in mind, this research work aimed to carry out specific formulation studies to design standard operating procedures for the preparation and optimization of Cannabis-based galenic formulations. Both decoctions and oils were prepared under different operating conditions to identify the most efficient process for the production of formulations with a high concentration of decarboxylated delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Regarding Cannabis oil, a new procedure has been developed that allows significantly higher recovery rates for THC and CBD compared with those for water-based extraction methods (decoction) and those for oil-based methods currently in use. (Full article...)

Recently featured:

Next steps for access to safe, secure DNA synthesis
Japan Aerospace Exploration Agency’s public-health monitoring and analysis platform: A satellite-derived environmental information system supporting epidemiological study
Smart grids and ethics: A case study