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Anatomical pathology (or Anatomic pathology) is a medical specialty that is concerned with the gross, microscopic, chemical, immunologic, and molecular examination of organs, tissues, and whole bodies (as in autopsy) to determine the presence of disease. Italian scientist Giovanni Battista Morgagni is widely considered the founding father of anatomic pathology.

Anatomical pathology is one of two branches of pathology, the other being clinical pathology, the diagnosis of disease through the laboratory analysis of bodily fluids. Often, pathologists practice both anatomical and clinical pathology, a combination known as general pathology. The distinction between anatomic and clinical pathology is increasingly blurred by the introduction of technologies that require new expertise and the need to provide patients and referring physicians with integrated diagnostic reports.

The procedures used in anatomic pathology include gross examination, histopathology, immunohistochemistry, in situ hybridization, cytopathology, electron microscopy, tissue cytogenetics, and flow immunophenotyping. Anatomic pathology differs from clinical pathology in several ways, often led by the differentiation in laboratory workflow. (Full article...)

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