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"A systematic framework for data management and integration in a continuous pharmaceutical manufacturing processing line"

As the pharmaceutical industry seeks more efficient methods for the production of higher value therapeutics, the associated data analysis, data visualization, and predictive modeling require dependable data origination, management, transfer, and integration. As a result, the management and integration of data in a consistent, organized, and reliable manner is a big challenge for the pharmaceutical industry. In this work, an ontological information infrastructure is developed to integrate data within manufacturing plants and analytical laboratories. The ANSI/ISA-88 batch control standard has been adapted in this study to deliver a well-defined data structure that will improve the data communication inside the system architecture for continuous processing. All the detailed information of the lab-based experiment and process manufacturing—including equipment, samples, and parameters—are documented in the recipe. This recipe model is implemented into a process control system (PCS), data historian, and electronic laboratory notebook (ELN). (Full article...)

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