Difference between revisions of "Template:Article of the week"

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(Updated article of the week text.)
(Updated article of the week text.)
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<div style="float: left; margin: 0.5em 0.9em 0.4em 0em;">[[File:Fig1 Reid BMCInformatics2014 15.jpg|220px]]</div>
<div style="float: left; margin: 0.5em 0.9em 0.4em 0em;">[[File:Fig2 SinghBMCBioinformatics2015 12-6.png|220px]]</div>
'''"[[Journal:Launching genomics into the cloud: Deployment of Mercury, a next generation sequence analysis pipeline|Launching genomics into the cloud: Deployment of Mercury, a next generation sequence analysis pipeline]]"'''
'''"[[Journal:SaDA: From sampling to data analysis—An extensible open source infrastructure for rapid, robust and automated management and analysis of modern ecological high-throughput microarray data|SaDA: From sampling to data analysis—An extensible open source infrastructure for rapid, robust and automated management and analysis of modern ecological high-throughput microarray data]]"'''


Massively parallel DNA sequencing generates staggering amounts of data. Decreasing cost, increasing throughput, and improved annotation have expanded the diversity of genomics applications in research and clinical practice. This expanding scale creates analytical challenges: accommodating peak compute demand, coordinating secure access for multiple analysts, and sharing validated tools and results.
One of the most crucial characteristics of day-to-day [[laboratory]] information management is the collection, storage and retrieval of [[information]] about research subjects and environmental or biomedical samples. An efficient link between sample data and experimental results is absolutely important for the successful outcome of a collaborative project. Currently available software solutions are largely limited to large scale, expensive commercial [[Laboratory information management system|Laboratory Information Management Systems]] (LIMS). Acquiring such LIMS indeed can bring laboratory information management to a higher level, but most of the times this requires a sufficient investment of money, time and technical efforts. There is a clear need for a light weighted open source system which can easily be managed on local servers and handled by individual researchers. Here we present a software named SaDA for storing, retrieving and analyzing data originated from microorganism monitoring experiments. SaDA is fully integrated in the management of environmental samples, oligonucleotide sequences, microarray data and the subsequent downstream analysis procedures. It is simple and generic software, and can be extended and customized for various environmental and biomedical studies. ('''[[Journal:SaDA: From sampling to data analysis—An extensible open source infrastructure for rapid, robust and automated management and analysis of modern ecological high-throughput microarray data|Full article...]]''')<br />
 
To address these challenges, we have developed the Mercury analysis pipeline and deployed it in local hardware and the Amazon Web Services cloud via the DNAnexus platform. Mercury is an automated, flexible, and extensible analysis workflow that provides accurate and reproducible genomic results at scales ranging from individuals to large cohorts.
 
By taking advantage of cloud computing and with Mercury implemented on the DNAnexus platform, we have demonstrated a powerful combination of a robust and fully validated software pipeline and a scalable computational resource that, to date, we have applied to more than 10,000 whole genome and whole exome samples. ('''[[Journal:Launching genomics into the cloud: Deployment of Mercury, a next generation sequence analysis pipeline|Full article...]]''')<br />


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''Recently featured'': [[Journal:Benefits of the community for partners of open source vendors|Benefits of the community for partners of open source vendors]], [[Journal:adLIMS: A customized open source software that allows bridging clinical and basic molecular research studies|adLIMS: A customized open source software that allows bridging clinical and basic molecular research studies]], [[Journal:MendeLIMS: A web-based laboratory information management system for clinical genome sequencing|MendeLIMS: A web-based laboratory information management system for clinical genome sequencing]]
''Recently featured'': [[Journal:Launching genomics into the cloud: Deployment of Mercury, a next generation sequence analysis pipeline|Launching genomics into the cloud: Deployment of Mercury, a next generation sequence analysis pipeline]], [[Journal:Benefits of the community for partners of open source vendors|Benefits of the community for partners of open source vendors]], [[Journal:adLIMS: A customized open source software that allows bridging clinical and basic molecular research studies|adLIMS: A customized open source software that allows bridging clinical and basic molecular research studies]]

Revision as of 18:14, 15 February 2016

Fig2 SinghBMCBioinformatics2015 12-6.png

"SaDA: From sampling to data analysis—An extensible open source infrastructure for rapid, robust and automated management and analysis of modern ecological high-throughput microarray data"

One of the most crucial characteristics of day-to-day laboratory information management is the collection, storage and retrieval of information about research subjects and environmental or biomedical samples. An efficient link between sample data and experimental results is absolutely important for the successful outcome of a collaborative project. Currently available software solutions are largely limited to large scale, expensive commercial Laboratory Information Management Systems (LIMS). Acquiring such LIMS indeed can bring laboratory information management to a higher level, but most of the times this requires a sufficient investment of money, time and technical efforts. There is a clear need for a light weighted open source system which can easily be managed on local servers and handled by individual researchers. Here we present a software named SaDA for storing, retrieving and analyzing data originated from microorganism monitoring experiments. SaDA is fully integrated in the management of environmental samples, oligonucleotide sequences, microarray data and the subsequent downstream analysis procedures. It is simple and generic software, and can be extended and customized for various environmental and biomedical studies. (Full article...)


Recently featured: Launching genomics into the cloud: Deployment of Mercury, a next generation sequence analysis pipeline, Benefits of the community for partners of open source vendors, adLIMS: A customized open source software that allows bridging clinical and basic molecular research studies