User:Shawndouglas/sandbox/sublevel6

AB Sciex Pte. Ltd.

Main landing page for cannabis testing: https://sciex.com/applications/food-and-beverage-testing/cannabis-testing

Commonly known as Sciex, AB Sciex Pte. Ltd. develops "solutions in mass spectrometry paired with capillary electrophoresis and liquid chromatography." The company markets some of its solutions for cannabis lab testing, including:

• potency testing
• mycotoxin testing
• pesticide testing
• terpenes testing

Instruments and methods

Triple Quad systems

Sciex offers four different Triple Quad systems for tandem mass spectrometry paired with liquid chromatography (LC-MS/MS): the 6500+, 5500, 4500, and 3500. The company claims that with these systems "scientists can acquire multiple reaction monitoring (MRM), precursor, neutral loss, and product ion scans to develop powerful methods for complex matrices, all while maintaining reproducibility and robustness."

• 6500+
• 5500
• 4500
• 3500

QTRAP systems

Sciex also offers three different Triple Quad Linear Ion Traps (QTRAP) systems for LC-MS/MS: the 6500+, 5500, and 4500. The company states that these are similar to the Triple Quad systems "but with enhanced scan functions to enable simultaneous quantitation and confirmation."

• QTRAP 6500+
• QTRAP 5500
• QTRAP 4500

vMethod for Cannabis

Sciex also offers a "vMethod," a quantitation method for pesticide and cannabinoid analysis, that works on many of their LC-MS/MS systems.

Agilent Technologies, Inc.

Main landing page for cannabis testing: https://www.agilent.com/en/promotions/cannabis

Agilent Technologies, Inc. is an instrument and software development company for the life sciences, diagnostics, and applied chemical industries. The company offers a variety of chromatography and spectrometry instruments (using a wide array of techniques) and software for the cannabis testing industry, including:

• potency and efficacy testing
• heavy metals testing
• pesticide testing
• residual solvents testing
• terpenes testing

Instruments and methods

The company suggests instrument options based on what type of testing will occur.

Potency and efficacy testing

• 1260 Infinity II SFC System: a supercritical fluid chromatography (SFC) system with an ultra-high performance liquid chromatography (UHPLC) power range
• 1290 Infinity II LC System: an UHPLC system
• 1290 Infinity II 2D-LC System: similar to the prior, but with two-dimensional liquid chromatography
• 5977B GC/MSD: a single-quadrupole GC/MS system with an electron ionization (EI) source
• Cary 630 FTIR Spectrometer: portable fourier-transform infrared (FTIR) spectroscopy
• Intuvo 9000 GC System: an ultra-fast gas chromatography system

Heavy metals testing

• 5110 ICP-OES Instrument: an inductively coupled plasma optical emission spectrometry (ICP-OES) instrument with synchronous radial and axial measurement
• 7800 ICP-MS: an inductively coupled plasma mass spectrometry (ICP-MS) instrument
• 7900 ICP-MS: an inductively coupled plasma mass spectrometry (ICP-MS) instrument with higher matrix tolerance, wider dynamic range, and better signal-to-noise ratio
• 8900 Triple Quadrupole ICP-MS: an inductively coupled plasma normal and tandem mass spectroscopy instrument with triple quadrupole

Pesticide testing

• 6400 Triple Quadrupole LC/MS: liquid chromatography normal and tandem mass spectrometry instruments, with four variations (6420A, -60C, -70A, and 95B)
• 6500 Series Accurate-Mass Quadrupole Time-of-Flight (Q-TOF) LC/MS: quadrupole time-of-flight liquid chromatography-mass spectrometry instruments, with five variations (6530, -45, -45XT, -50, and -60)
• 7000D Triple Quadrupole GC/MS: a gas chromatography normal and tandem mass spectroscopy instrument with triple quadrupole and dynamic MRM
• GC/MS/MS Pesticides Analyzer: a gas chromatography tandem mass spectroscopy instrument with triple quadrupole

Residual solvents testing

• 7890 Series GC with 7697A Headspace Sampler and Flame Ionization Detector: a gas chromatography instrument combined with the 7697A Headspace Sampler and compatible flame ionization detector

Terpenes

• 1260 Infinity II Diode Array Detector HS: a liquid chromatography high-sensitivity diode array detector
• 1260 Infinity II Diode Array Detector WR: a liquid chromatography wide-range diode array detector
• 7890 Series GC: a gas chromatography instrument
• Intuvo 9000 GC System: an ultra-fast gas chromatography system

Software

• ICP Expert Software for ICP-OES: inductively coupled plasma optical emission spectrometry (ICP-OES) software for data analysis
• MassHunter: mass spectrometry software for instrument control, monitoring, and data analysis
• MicroLab: fourier-transform infrared spectroscopy software for quantitative method development, calibrations, and data analysis

BÜCHI Labortechnik AG

Main landing page for cannabis production: https://www.buchi.com/en/cannabis-application-booklet

BÜCHI Labortechnik AG is laboratory technology development company for research and development, quality control, and production operations globally. The company offers a variety of instruments and equipment for cannabis production workflow, including:

• post-chromatography and post-extraction solvent concentration
• preperative chromatography for purification of cannabinoids
• microencapsulation of CBD into gelatin beads/soft oil core capsules
• formulation of CBD into an inhalable/edible dry powder

See the Theory & Applications booklet (main landing page) for more details on how to integrate the equipment for each activity.

Instruments and methods

The company suggests instrument options based on what type of production activity will occur.

Post-chromatography and post-extraction solvent concentration

• Rotavapor R-220 Pro: an industrial evaporator with programmable methods, automatic distillation, and remote monitoring options
• F-325 Recirculating Chiller
• V-600 Vacuum Pump

Preparative chromatography for purification of cannabinoids

• Reveleris X2: flash column chromatography for separations and flash purification; more advanced than the Sepacore
• Sepacore Flash Systems X10/X50: flash column chromatography for separations and flash purification
• C-601 Pump
• C-650 ELS Detector: an evaporative light scattering detector for any mobile phase or gradient

Microencapsulation of CBD into gelatin beads/soft oil core capsules

• Encapsulator B-390
• Encapsulator B-395 Pro
• Rotavapor R-300: a rotary evaporator
• Interface I-300 Pro
• F-305 Recirculating Chiller
• V-300 Vacuum Pump

Formulation of CBD into an inhalable/edible dry powder

• B-290 Mini Spray Dryer
• B-295 Inert Loop

CEM Corporation

Main landing page for cannabis testing: http://cem.com/cannabis

CEM Corporation is laboratory instrumentation and method design and development company, with a focus on compositional analysis of food and other samples, as well acid digestion and chemical synthesis. CEM specifically offers two different instruments for cannabis testing and analysis labs, including instruments for the:

• extraction for potency, pesticide, terpene, and mycotoxin testing
• microwave digestion of oils, edibles, and plant material (before, e.g., inductively coupled plasma mass spectroscopy)

Instruments and methods

• EDGE: an automated instrument for energized dispersive extraction and dispersive solid-phase extraction (dSPE)
• MARS 6: a microwave digestion system with hundreds of preprogrammed methods

Emerald Scientific, LLC

Main landing page for cannabis testing: https://emeraldscientific.com/

Emerald Scientific, LLC calls their business "[t]he first and only company 100% dedicated to distributing scientific supplies and equipment to the cannabis industry." The company lists a wide variety of instruments, equipment, and consumables for cannabis testing, production, and extraction laboratories. Emerald acts as a distributor of other products, and thus the inventory may change. Examples of inventory include:

• sample preparation supplies
• solvents
• mass spectrometry columns
• heating mantles
• chillers and circulators
• vacuum pumps and tubing
• reference standards
• culture media
• safety equipment

Consult the Emerald website to see all they offer.

Fritsch GmbH

Main landing page for cannabis testing: https://www.fritsch-international.com/sample-preparation/applications-solutions/ (select "Cannabis" from Industry option)

Fritsch GmbH manufactures sample preparation and particle sizing equipment for laboratories. The company lists one instrument specifically for the cannabis industry.

Instruments and methods

• Universal Cutting Mill PULVERISETTE 19: a cutting mill "to finely mill cannabis plant material in preparation for SFE processes," noting that "[t]he efficient and precise reduction in particle size optimizes oil output and formulation."

GemmaCert Ltd.

Main landing page for cannabis testing: https://gemmacert.com/

GemmaCert Ltd. is a cannabis testing technology company that markets the GemmaCert analysis tool.

Instruments and methods

• GemmaCert: a portable near-infrared spectroscopy instrument designed to analyze total THC and total CBD levels, without destroying the inserted specimen