File:Fig2 Pickering LancetMicrobe2021 2-9.jpg
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Summary
| Description |
Figure 2. Comparison of Ct value, infectivity, and rapid antigen test result. (A) Infectivity, N Ct value, and antigen test results for three commercial tests. Bars show the N Ct result for each swab in ascending order, colored according to whether virus was cultured from the sample. Antigen test results for each sample are shown below each bar. Sensitivity determinations for the sample set are shown on the right. (B) Direct viral titers of swabs determined by plaque assay and compared with N Ct value. The linear relationship between Ct value and log10 concentration of infectious virus in 57 samples is shown. (C) Ct results from (A) and RNA copies per mL plotted against days from symptom onset. Points are colored according to virus growth (left graph; n = 141) or the score derived from the Innova antigen test (right graph; n = 110). (D) Longitudinal examples of infectivity, antigen test positivity, and Ct values for five infected individuals with varying COVID-19 severities. Bars show the N Ct value for each sample, shaded according to virus culture result. Antigen test results for each sample are shown below the bars. N = SARS-CoV-2 nucleocapsid; Ct = cycle threshold; SureScreen-F = SureScreen fluorescent; SureScreen-V = SureScreen visual. * = Less than total sample due to limited sample volume or number of test kits available. † = Time post-onset of symptoms for symptomatic individuals; time from the first positive PCR test for asymptomatic individuals. ‡ = Sufficient sample volume and test availability for inclusion in the longitudinal study for completeness of the dataset. |
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| Source |
Pickering, S.; Batra, R.; Merrick, B. et al. (2021). "Comparative performance of SARS-CoV-2 lateral flow antigen tests and association with detection of infectious virus in clinical specimens: A single-centre laboratory evaluation study". The Lancet Microbe 2 (9): e461-e471. doi:10.1016/S2666-5247(21)00143-9. |
| Date |
2021 |
| Author |
Pickering, S.; Batra, R.; Merrick, B. et al. |
| Permission (Reusing this file) |
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Licensing
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This work is licensed under the Creative Commons Attribution 4.0 License. |
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