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Developer(s) Yuriy Vaskin et al.
Initial release September 2011 (2011-09) (1.0)[1]
Written in Java
Operating system Cross-platform
Type Laboratory informatics software
License(s) MIT License

SMITH (Sequencing Machine Information Tracking and Handling) was free open-source laboratory information management system (LIMS) software for sequencing applications, originally designed for the Italian Institute of Technology and the European Institute of Oncology.[1]

Product history

The first version of SMITH was deployed at the Italian Institute of Technology (IIT) and the European Institute of Oncology (EIO) in September 2011. On February 5, 2014, the developers ported the source code to Bitbucket and made it available under the MIT license.[2]

The development team reported in 2014 that SMITH had been used at IIT and EIO to process more than 4000 samples sequenced on 170 flow cells.[1]

As of May 2021, no code updates had been made since 2015. The project is presumed to be abandoned or discontinued.


According to the associated journal article, the following were some of the features of SMITH[1]:

  • Sample submission
  • Sample annotation
  • Sample analysis
  • Sample tracking
  • Project awareness
  • Run folder monitoring
  • Quality control
  • Reagent storage
  • Role-based access
  • Virtual flow cells
  • Index compatibility testing
  • Email alerts

The team also noted the following: "Adaptation of SMITH for use with alternative sequencing platforms likely requires a limited set of changes in the script generator, which is tailor-made for Illumina sequencers in the current implementation."[1]

Hardware/software requirements

According to the source code documentation, SMITH required the following for the source:

The following was required for installing the application:

Videos, screenshots, and other media

Entities using SMITH

European Institute of Oncology; Italian Institute of Technology

Further reading

External links


  1. 1.0 1.1 1.2 1.3 1.4 Venco, Francesco; Vaskin, Yuriy; Ceol, Arnaud; Muller, Heiko (2014). "SMITH: a LIMS for handling next-generation sequencing workflows". BMC Bioinformatics 15 (Suppl 14): S3. doi:10.1186/1471-2105-15-S14-S3. PMC PMC4255740. Retrieved 04 November 2015. 
  2. "SMITH - Commits - Initial Import". Bitbucket. 5 February 2014. Retrieved 04 November 2015.