Histopathology

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Histopathology is a branch of histology and pathology that studies and diagnoses diseases on the tissue and cellular level. While histopathology is closely related to cytopathology, the main difference is diagnostic information gained from histopathology is acquired from solid tissue samples, whereas specific disaggregated cell preparations are used in cytopathology.[1] Typically a biopsy or surgical specimen is examined by a pathologist after the specimen has been processed and histological sections have been placed onto glass slides.

Rudolf Ludwig Karl Virchow is considered by many to be one of the fathers of cellular pathology, remembered most for his collection of lectures on the topic, published as Cellular Pathology in 1858.[2][3] However, his assistant, David Paul von Hansemann also played an important role in the progress of histopathology during the 1890s, producing his book The Microscopic Diagnosis of Malignant Tumours and other important research.[4][5]

Testing

Collection

Preparation

Staining

Dehydration, clearing, and mounting

Examination

References

  1. Orchard, Guy; Nation, Brian (eds.) (2011). Histopathology. Oxford University Press. p. 3. ISBN 9780199574346. http://books.google.com/books?id=qWScAQAAQBAJ&pg=PA3. Retrieved 18 April 2014. 
  2. "Rudolf Virchow — father of cellular pathology". Journal of the Royal Society of Medicine 86 (12): 688–689. December 1993. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1294355/?page=1. Retrieved 17 April 2014. 
  3. Virchow, Rudolf Ludwig Karl (1860). Cellular Pathology as Based Upon Physiological and Pathological Histology. John Churchill. http://books.google.com/books?id=nmEGHJy9uswC&printsec=frontcover. Retrieved 17 April 2014. 
  4. Bignold, Leon P.; Coghlan, Brian L. D.; Jersmann, Hubertus P.A. (2007). David Paul von Hansemann: Contributions to Oncology: Context, Comments and Translations. Springer. p. xii. ISBN 9783764377694. http://books.google.com/books?id=i2fEpOXxgvkC&pg=PR12&lpg=PR12. Retrieved 18 April 2014. 
  5. Edmundson, Walter F. (February 1948). "Microscopic Grading of Cancer and Its Practical Implication". Archives of Dermatology and Syphilology 57 (2): 141–150. doi:10.1001/archderm.1948.01520140003001. http://archderm.jamanetwork.com/article.aspx?articleid=521834. Retrieved 18 April 2014.