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'''"[[Journal:Defending our public biological databases as a global critical infrastructure|Defending our public biological databases as a global critical infrastructure]]"'''
<div style="float: left; margin: 0.5em 0.9em 0.4em 0em;">[[File:Fig1 Signoroni NatComm23 14.png|240px]]</div>
'''"[[Journal:Hierarchical AI enables global interpretation of culture plates in the era of digital microbiology|Hierarchical AI enables global interpretation of culture plates in the era of digital microbiology]]"'''


Progress in modern biology is being driven, in part, by the large amounts of freely available data in public resources such as the International Nucleotide Sequence Database Collaboration (INSDC), the world's primary database of biological sequence (and related) [[information]]. INSDC and similar databases have dramatically increased the pace of fundamental biological discovery and enabled a host of innovative therapeutic, diagnostic, and forensic applications. However, as high-value, openly shared resources with a high degree of assumed trust, these repositories share compelling similarities to the early days of the internet. Consequently, as public biological databases continue to increase in size and importance, we expect that they will face the same threats as undefended cyberspace. There is a unique opportunity, before a significant breach and loss of trust occurs, to ensure they evolve with quality and security as a design philosophy rather than costly “retrofitted” mitigations. This perspective article surveys some potential quality assurance and security weaknesses in existing open [[Genomics|genomic]] and [[Proteomics|proteomic]] repositories, describes methods to mitigate the likelihood of both intentional and unintentional errors, and offers recommendations for risk mitigation based on lessons learned from [[cybersecurity]]. ('''[[Journal:Defending our public biological databases as a global critical infrastructure|Full article...]]''')<br />
Full [[laboratory automation]] is revolutionizing work habits in an increasing number of clinical [[microbiology]] facilities worldwide, generating huge streams of [[Imaging|digital images]] for interpretation. Contextually, [[deep learning]] (DL) architectures are leading to paradigm shifts in the way computers can assist with difficult visual interpretation tasks in several domains. At the crossroads of these epochal trends, we present a system able to tackle a core task in clinical microbiology, namely the global interpretation of diagnostic [[Bacteria|bacterial]] [[Cell culture|culture]] plates, including presumptive [[pathogen]] identification. This is achieved by decomposing the problem into a hierarchy of complex subtasks and addressing them with a multi-network architecture we call DeepColony ... ('''[[Journal:Hierarchical AI enables global interpretation of culture plates in the era of digital microbiology|Full article...]]''')<br />
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Latest revision as of 15:02, 3 June 2024

Fig1 Signoroni NatComm23 14.png

"Hierarchical AI enables global interpretation of culture plates in the era of digital microbiology"

Full laboratory automation is revolutionizing work habits in an increasing number of clinical microbiology facilities worldwide, generating huge streams of digital images for interpretation. Contextually, deep learning (DL) architectures are leading to paradigm shifts in the way computers can assist with difficult visual interpretation tasks in several domains. At the crossroads of these epochal trends, we present a system able to tackle a core task in clinical microbiology, namely the global interpretation of diagnostic bacterial culture plates, including presumptive pathogen identification. This is achieved by decomposing the problem into a hierarchy of complex subtasks and addressing them with a multi-network architecture we call DeepColony ... (Full article...)
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