Journal:2019 novel coronavirus disease (COVID-19): Paving the road for rapid detection and point-of-care diagnostics
Full article title | 2019 novel coronavirus disease (COVID-19): Paving the road for rapid detection and point-of-care diagnostics |
---|---|
Journal | Micromachines |
Author(s) | Nguyen, Trieu; Bang, Dang Duong; Wolff, Anders |
Author affiliation(s) | Technical University of Denmark |
Primary contact | Email: awol at dtu dot dk |
Year published | 2020 |
Volume and issue | 11(3) |
Article # | 306 |
DOI | 10.3390/mi11030306 |
ISSN | 2072-666X |
Distribution license | Creative Commons Attribution 4.0 International |
Website | https://www.mdpi.com/2072-666X/11/3/306/htm |
Download | https://www.mdpi.com/2072-666X/11/3/306/pdf (PDF) |
This article should be considered a work in progress and incomplete. Consider this article incomplete until this notice is removed. |
Abstract
We believe a point-of-care (PoC) device for the rapid detection of the 2019 novel coronavirus (SARS-CoV-2) is crucial and urgently needed. With this perspective, we give suggestions regarding a potential candidate for the rapid detection of the coronavirus disease 2019 (COVID-19), as well as factors for the preparedness and response to the outbreak of COVID-19.
Keywords: COVID-19, Wuhan, 2019 novel coronavirus, point-of-care detection, SARS-CoV-2, loop-mediated isothermal amplification, LAMP assay, polymerase chain reaction, PCR
Introduction
On January 30, 2020, the World Health Organization (WHO) declared a global public health emergency [1] over the outbreak of a novel coronavirus, called the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (previously "2019 novel coronavirus" or "2019-nCoV"), which originated in Wuhan City, in the Hubei Province of China. On February 11, WHO officially named the disease the coronavirus disease 2019 (COVID-19). [2] Human-to-human transmission (Figure 1) has been confirmed by WHO and by the Centers for Disease Control and Prevention (CDC) of the United States [3], with evidence of person-to-person transmission from three different cases outside China, namely in the U.S. [4], Germany [5], and Vietnam [6].
|
COVID-19 has continuously spread to 104 countries; the number of confirmed infections reached 109,343 on March 9, 2020 [7], and the death toll in China has overtaken the SARS epidemic of 2002–2003 and has risen to 3,100 [2]. To slow down the spread of COVID-19, at least 50 million people in China have been placed under lockdown. [8] On March 8, 2020, Italy also undertook the same measures, with the northern part of the country getting placed under lockdown, affecting 16 million people. [9] The reproduction number R0 (i.e., the average number of secondary cases generated by a typical infectious individual) is estimated to be 2.68, and the doubling time is estimated to be 6.4 days. [10]
The difference in terminology between "coronavirus" and "SARS-Cov-2" is detailed in Table 1.
|
References
Notes
This presentation is faithful to the original, with only a few minor changes to presentation. In some cases important information was missing from the references, and that information was added.