Journal:Electronic lab notebooks: Can they replace paper

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Full article title Electronic lab notebooks: Can they replace paper?
Journal Journal of Cheminformatics
Author(s) Kanza, Samantha; Willoughby, Cerys; Gibbins, Nicholas; Whitby, Richard;
Frey, Jeremey Gramaham; Erjavec, Jana; Zupančič, Klemen; Kovač, Katarina
Author affiliation(s) University of Southampton, BioSistemika
Primary contact Email: sk11g08 at soton dot ac dot uk
Year published 2017
Volume and issue 9
Page(s) 31
DOI 10.1186/s13321-017-0221-3
ISSN 1758-2946
Distribution license Creative Commons Attribution 4.0 International
Download (PDF)


Despite the increasingly digital nature of society, there are some areas of research that remain firmly rooted in the past; in this case the laboratory notebook, the last remaining paper component of an experiment. Countless electronic laboratory notebooks (ELNs) have been created in an attempt to digitize record keeping processes in the lab, but none of them have become a "key player" in the ELN market, due to the many adoption barriers that have been identified in previous research and further explored in the user studies presented here. The main issues identified are the cost of the current available ELNs, their ease of use (or lack of it), and their accessibility issues across different devices and operating systems. Evidence suggests that whilst scientists willingly make use of generic notebooking software, spreadsheets, and other general office and scientific tools to aid their work, current ELNs are lacking in the required functionality to meet the needs of researchers. In this paper we present our extensive research and user study results, proposing an ELN built upon a pre-existing cloud notebook platform that makes use of accessible popular scientific software and semantic web technologies to help overcome the identified barriers to adoption.

Keywords: electronic laboratory notebooks (ELNs), notebooking software, cloud, semantic web, scientific software


In scientific research, communication is essential between researchers, funding bodies, industry, and members of the public. Ideas need to be shared, evidence disseminated, plans discussed, findings recorded, and errors corrected. Researchers may work alone, but their research is of little value to the scientific community if it isn't disseminated. The scientific record can act as a legally binding record that protects intellectual property (IP).[1] Historically the paper laboratory notebook and the scientific paper have been at the center of this scientific communication[2]; however, this is being slowly replaced by the arrival of digital technologies and the internet, the web in particular.[3]

Digital technologies are shaping the way experiments are performed, results are captured, and findings are disseminated. Computers enable a myriad of functions that benefit researchers and scientists: they can be searched, shared, easily backed up, and readily accessed.[4] They facilitate interactive computation, electronic communication, multimedia distribution, and digital information management.[5] Within the lab, instruments are mostly computer controlled; computers are the main tools for capturing, analyzing, and annotating data. Electronic laboratory notebooks (ELNs) are also transforming the way that the scientific record is captured, with a revolutionary transformation from paper notebooks to the digital capture of experiments.[6]

ELNs offer significant benefits to researchers by facilitating long-term storage, reproducibility, and enhanced availability of experiment records across multiple devices, ensuring standard operating procedure compliance and providing interfaces to instrumentation, supporting IP protection, collaboration, and open science.[7][8][9][10][11] ELNs eliminate the need for manual transcription and can be used by distributed groups[12], facilitate managing notes, and simplify the inclusion and curation of digital resources (e.g., instrument data, analysis results).[13] While some systems are restricted to repositories of raw data and results, others have the potential to support researchers through the whole experiment lifecycle.[14][15]

More recently, semantic lab notebooks (SLNs) have utilized semantic web technologies to expose research data as formalized metadata[16], and to link between the different data sets collected throughout the experimental process.[17] Incorporating semantic web technologies within ELNs, using RDF and ontologies to enrich the data with meaning and context, provides new functionality such as making inferences about experiment types and creates valuable links between experiment outcomes and their final reports.[12][13][15][16][18] Making ELN data machine readable increases interoperability, facilitates integration with third-party tools, and enables automatic generation of materials for deposition in an archive or publication[16], increasing the usefulness of the tools for researchers.

Although ELNs are being increasingly used for industrial research, uptake in academia is limited.[19][20] This paper explores the current offerings of ELNs and electronic notebook software. We conducted studies to investigate the attitudes of academics towards ELNs and their desired functionality. It presents an overview of the barriers to adoption within academic environments, researcher behavior, and key features for ELNs. Following these findings, we discuss priorities for future ELN development and propose our semantic platform-based ELN solution. Table 1 introduces the user studies that will be discussed in this paper.

Table 1. A table describing the different user studies that have been detailed in this paper
Study Study dates No. of participants Description
A — BioSistemika’s Webinar Survey[21] Oct. 2015 and Feb. 2016 228 Survey of current ELN usage
B — BioSistemika’s ELN Survey Mar. – Apr. 2015 196 Survey of ELN features, costs and barriers
C — University of Southampton’s ELN study Summer 2016 103 ELNs Study of the current ELN market: active/inactive ELNs, ELN licensing, and platforms
D — University of Southampton lab practice study (focus groups and lab observations) Nov. 2016 – Mar. 2017 33 Focus groups with physicists, chemists, and biologists; lab observations of four different chemistry labs at the University to better understand current lab practice
E — University of Southampton’s Dial-a-Molecule (DaM) Survey and iLabber Pilot Project Sept. 2011 Initial survey: 88; start of trial: 92; end of trial: 93 Surveys to gain knowledge and understand attitudes towards using ELNs and issues identified with using the trialed ELN
F — University of Southampton’s Communities Survey 2010 – 2015 94 Full details of this study can eventually be found in Willoughby and Frey (in preparation)[22]

The market today

The current ELN market is supersaturated with choice; however, despite the wide range of products available, there is no obvious "leader." Additionally, the scientific community is still resistant to using ELNs, despite the popularity of electronic notebooks. Electronic notebooks that have been subverted to ELN usage, current ELN offerings, and the attitudes to ELNs and their current usage are examined and detailed in this section.

Electronic notebooks

Today’s market has multiple offerings for electronic notebooks: Microsoft Word, Office 365, Google Docs, Evernote[23], and OneNote[24], which have been evaluated for use as ELNs.[25][26][27] Oleksik et al.’s[25] study reported that the collaborative features of OneNote facilitated faster and easier sharing, and they enabled simultaneous communication between researchers, irrespective of location. Users trialing Evernote as an ELN[27] said they appreciated the electronic affordances such as "accessible from any online computer" and "ability to search" but found that it was lacking in domain knowledge, stating that it was "simple and practical for some laboratories, but for others it does not offer features specialized for fields such as biology, chemistry, or quality assurance/quality control." A balance may need to be struck between making an ELN usable across multiple disciplines, whilst still providing enough domain-specific knowledge.

Whilst there are many attractive affordances of storing your notes electronically, it is of concern to researchers whether their data is kept truly private or not, once it has been put into these services. Service providers differ in their privacy policies. For example, Google Docs states that not only do the users maintain intellectual property of any content they create, content will not be shared with any third parties, and the user can take their data with them if they choose to leave Google Docs.[28] However, other services such as Microsoft Office 365 may give contracted third parties access to their customer data (which includes both personal data such as names and email addresses, but also data uploaded into their systems such as images and documents) to perform certain services.[29] An example of a privacy policy controversy is Evernote, where the default was for their employees to be able to read users' content to ascertain the accuracy of their machine learning algorithms.[30] It is important for researchers to be aware of privacy policies and to ensure that research data is secure and can't be read by third parties when using any software.

Electronic lab notebooks

Southampton University’s ELN Market study identified 103 ELNs[31][32][33][17], 72 active and 30 no longer active, either due to discontinuation or acquisition by larger companies. The active ELNs were further investigated to see which domains they supported, as well as their platform and licensing availability (Figs. 1, 2).

Fig1 Kanza JofCheminformatics2017 9.gif

Figure 1. A chart illustrating the different domains represented by the active ELNs in the market

Fig2 Kanza JofCheminformatics2017 9.gif

Figure 2. A chart illustrating the licensing and platform information across the active ELNs in the market

The different licensing categories and associated considerations are as follows:

  • Paid for: This is a proprietary piece of software that can be purchased, which may use proprietary data formats.
  • Paid (with free version): This is a proprietary piece of software that can be purchased, but which also has a version of this software which can be used for free; either as a trial for a fixed period of time, or a version that has reduced functionality.
  • Open-source: This is a product where the code behind the actual software has been made openly available so that anyone can redistribute it and edit it as long as they conform to the licensing conditions. Open-source products are often free, but not always, and they may use either standard or proprietary data formats.
  • Free: This is a product which is free to use.

These findings illustrate an array of ELNs ranging from supporting specific disciplines (such as [[eNovalys SAS|eNovalys]' LabBook[34], which is aimed at chemists), to providing all-purpose solutions (such as KineMatik's eNovator ELN[35], which aims to provide a multipurpose ELN that can be used in many different areas). However, a common factor is that most of these ELNs require payment. Additionally, slightly over 60 percent of them are web-based/platform-independent, with the rest only available on certain operating systems or without a disclosure of their platform compatibility.

There appears to be a proclivity towards ELNs that make use of pre-existing software. NuGenesis allows users to drag and drop Excel and Word files into their ELN, eLabJournal provides Excel inside its ELN, and Limsophy uses Microsoft Word templates. This illustrates an increasing awareness that scientists do use notebooking software, even if they don't specifically use ELNs. Additionally, it suggests that there is a place for ELNs during the final write-up process, as well as during the physical experimental process. These ideas will be explored further in the "Proposal" section. In addition to the market investigations, current ELN usage was also researched. BioSistemika investigated ELN usage, and the DaM survey looked at attitudes towards ELNs.

ELN usage and barriers to adoption

Despite the saturated ELN market, results from the BioSistemika and DaM surveys indicated that whilst a large percentage of academic users are considering or interested in using ELNs (as shown in Fig. 3; Table 2), they are lacking in uptake in academia.[19][20] Many scientists extensively use computers yet continue to use paper notebooks throughout their experiments, highlighting that computer illiteracy or an aversion to technology cannot fully explain resistance to ELNs.[36][37][38]

Fig3 Kanza JofCheminformatics2017 9.gif

Figure 3. The results of the BioSistemika Webinars: Are you using electronic laboratory notebooks (ELNs) in your daily lab routine?

Table 2. Attitudes towards ELNs from the respondents of the Dial-a-Molecule’s "Potential use of ELNs in Academia" Survey
ELN attitudes %
Awareness of ELNs 98
Using an ELN in their research group 11
Strong interest in implementing one or finding out more about them 76

The University of Southampton’s Lab Practice Study asked users about their ELN usage and experiences. Some participants had used ELNs such as LocalWiki, LabTrove, Blog3, BioBook (now E-WorkBook), LabBook and an industrial one on a short term basis. The industrial ELN was unfavorably described, whilst the other ELNS were only deemed useful for certain purposes. One participant found LabBook very useful for inorganic work but lacking the required functionality for their transport runs. Equally, participants who tried LabTrove and Blog3 found some of the elements useful in certain situations, but all defaulted back to Word documents. One participant suggested that this was the case because it did not contribute in a systematic way to their work.

There are therefore challenges and barriers to adoption of ELNs. Figure 4 and Table 3 illustrate the key barriers that our studies identified, and these are described in more depth in the following sections.

Fig4 Kanza JofCheminformatics2017 9.gif

Figure 4. The barriers of using an ELN from both a research lab and a diagnostic lab

Table 3. Categorized barriers of ELN adoption from the Dial a Molecule iLabber Pilot Project: Potential Uses of ELNs in Academia Survey
Category Barriers Percentage of 169 (%)
Cost Up front costs and licensing fees 74
Additional infrastructure costs (e.g., computers) 27
Future development and costs of applications 90
Ongoing costs of the system 93
ELN attitude Only makes sense if the whole department adopts it 20
Belief that students/post docs would resist adoption 11
Ease of use ELN was too difficult to use 22
Does not capture the right information for me 7
Difficult to capture some kinds of information in an ELN 80
ELN access You’d need to enter data in both the lab and write-up area 74
No easy access to appropriate hardware in the lab 12.5
Data compatibility Data will be tied into a commercial package 84
Other Other 11


As shown in Table 3, a large percentage of survey respondents indicated that cost was a significant barrier to ELN adoption.[7][19][20] This includes financial outlay, staff hours, troubleshooting, and the fact that long-term use is likely to require ongoing maintenance and support. There are also concerns about the required database administration and support, with suggestions that having professional IT staff to help with setup and maintenance would be pivotal.

One respondent experienced sharp price-increases in database maintenance and upgrade costs after an initial discount. Other concerns are service providers not competing to keep costs down and the potential cost of storage space, indicating disincentives if the University charges groups for storage space. Figure 4 illustrates a willingness to pay up to $50 a month for an ELN, but not $100, suggesting that ELNs reach a point where they are considered "too expensive" (Fig. 5).

Fig5 Kanza JofCheminformatics2017 9.gif

Figure 5. The maximum costs that the respondents of the BioSistemika’s ELN survey would be willing to pay for an ELN per month, from the perspective of those in research, and with purchasing power

Other comments queried whether funding was available for ELNs in universities, suggesting that web-based systems could significantly cut costs, as they require less hardware.

As evidenced by Fig. 2, while most of the ELNs available in the market are proprietary pieces of software that require purchasing, there are also some free and open-source offerings available. The free options would clearly have the advantage of being cheaper to run and test but may have disadvantages depending on the nature of the software. The paid-for and free software model (one of the categories in Fig. 2) will have enterprise users to generate its revenue, and are able to offer reduced free versions to other users to generate recognition, providing the benefits and stability of proprietary software with a potential lack of cost. However, the fear is that other standalone free offerings are more likely to disappear, potentially alongside the research data. Some of the inactive free ELNs that were identified as part of the University of Southampton’s ELN Study were listed on online sources[31][9] though with websites that had seemingly vanished with no new obvious location. Open-source software is often free (although not always) and has a significant advantage over proprietary software with respect to their potential longevity. Both open-source and proprietary projects will always be at risk of ceasing to continue, either due to lack of funds or the original developers leaving the project. However, given the licensing of open-source projects, which makes it possible to view and change the source code, other developers are able to access, update, and support the software.

Ease of use

Another challenge is the perceived "ease of use" of paper notebooks compared to electronic systems. Paper notebooks are considered easier to use, input data to, read, and transport, and they're also inexpensive, readily available, "turn on" instantly, have infinite battery life, are socially acceptable during meetings, and require no training and minimal IT support.[7][19][37][5][39][40] Whereas, ELN software for taking notes is considered more difficult to use, timely and less flexible, leading to anxieties about ELNs' stability, accessibility, and availability.[41]

Our interactions with researchers and ELN users demonstrate that ease of use is vital to adoption. In the DaM survey, 99% of respondents indicated that ease of use would influence their ELN choice, with almost 80% rating it as very important. One comment reflected the desire for a flexible generic solution, rather than an ELN designed for a specific research area, due to anxieties that their research "doesn’t fit neatly into one category."

Attitudes to ELNs

Adopting an ELN only makes sense if the whole department adopts it, which allows for sharing costs and training; repositories, consistency, and use of standards could also be relevant.[16][17] Several comments reflected their assumption of students and postgrads rejecting ELNs through "resistance to change in some groups," noting that some students didn’t like their experiences with ELN, and might consider using them as an "additional burden."

Access to ELNs

In the Uses of ELNs in Academia survey, 74% expressed concerns about needing to enter data in both the lab and write-up area, due to a lack of suitable hardware or software capabilities to facilitate ELN usage inside and outside the lab. This can lead to copying and pasting printouts into paper notebooks and manually transcribing data between notebooks and computers, which can result in data loss, transcription errors, and records stored haphazardly.[42][12] Popular suggestions were to use mobile computers or tablets for portability in and out of the lab, and that web-based ELNs could improve accessibility.

Lack of appropriate hardware access in the lab lead to 12.5% of participants in the Post Pilot Survey ceasing to use the trialed ELN, resulting in several needing to perform tasks manually. Other anxieties frequently raised included risk of damage or contamination, security, "hassle" of carrying laptops around, shortage of computers for sharing, lack of bench space for computers, ELN not supported on chosen mobile platform, and lack of WiFi access. Primary workarounds for these issues appeared to be printing out experiments, writing up experiments retrospectively, or using paper notebooks alongside the ELN.

Software and system integration and compatibility

Researchers use different operating systems, but both the ELN Market study and comments from the DaM survey revealed a lack of availability of ELNs for Macs. It was suggested that iPads could work as a shared notebook due to their ease of transport, although software would need to be compliant with iOS and other mobile platforms, or be web-based. A perceived barrier was linked to integrating ELNs with existing infrastructure. The DaM surveys had similar concerns that users might be expected to purchase new ELN software at each operating system upgrade, which could contribute to system costs, support costs, and additional training requirements.

Electronic pen data entry, integration with digital repositories for archiving purposes, and bibliographic management have also been mentioned with regards to integration with existing tools. The DaM Pilot Program elicited a need for software compatibility, database integration, electronic data, and other "common software" (e.g., Word and Excel), as well as options to purchase add-ons for increased functionality. Users found problems using the ELN on a 64-bit operating system and on Macs, or with Chemdraw, office attachments, and uploading photographs; one said "…it was too cumbersome to import files from our current systems." ELN data input seems to have been a recurring issue, alongside failings in basic expectations about data management that heightened existing anxieties.

Data compatibility and portability

In the DaM Pilot survey, just under 70% expressed concern about the ELN capturing information easily, with 81% considering automatic experiment data capture important. Comments indicated that capturing a range of data is important, while raising concerns about the difficulties of instrument integration, partly due to a lack of standards between different manufacturers. Many comments expressed frustrations about not being able to link to specific experimental data such as spectroscopic results.

Several comments indicated worries about the ability to extract and move data between different ELNS and machines; these concerns relate to price hikes with a provider, longevity of commercial packages, and changing institution. Other comments addressed issues of proprietary formats, including previous bad experiences of "being tied into data formats" or being left with only a PDF of their data, although the desired transfer formats differed between respondents. Some comments embraced the importance of open data and not being tied to a particular commercial package, suggesting an open-source ELN to resolve the problem. This suggests that researchers perceive open-source offerings to be more likely to use standard data formats rather than proprietary formats. Concerns were also expressed regarding accessing databases and notebooks across different machines, suggesting that users expect their information to be stored locally or in a centralized system, and they are concerned about data security.

What do users do?

What users say they do doesn’t always match their actions; therefore, after establishing the main adoption barriers, we investigated how the researchers actually worked. Four focus groups were run with 24 postgraduate chemists, physicists, and biologists to discuss their current practices. Additionally, four different chemistry labs were observed to see how scientists operated there.


We found that different researchers vary their working patterns and note-taking, and they have contrasting needs when it comes to sharing records with others. Therefore a "one size fits all" approach to tool design wouldn’t be effective. Tools need to provide considerable flexibility and customization to accommodate different needs. The high-level results of these activities across the different disciplines are presented in Table 4 and will be further discussed later on in this section.

Table 4. How the physicists, chemists and biologists who took part in the University of Southampton Focus Groups perform different work tasks with respect to whether they use paper or electronic systems
Category Tasks Biologists Chemists Physicists
Recording notes Experiment notes Paper: Lab book Paper: Lab book
Electronic: Data
Paper: Lab book
Electronic: Data
Thinking about work notes Paper: Lab book Paper: Lab book
Electronic: Google Tasks
Paper: Lab book
Electronic: Google Keep
Literature notes Paper: Print papers/handwritten notes
Electronic: Reference manager
Paper: Print papers/handwritten notes
Electronic: Reference manager
Paper: Print papers/handwritten notes
Electronic: Reference manager
Organizing notes Paper: Lab book by date/contents page Paper: Lab book by date/contents page
Electronic: By codes (linking to lab book) and by sample/experiment
Paper: Lab book by date/contents page
Electronic: By codes (linking to lab book) and by category/experiment
Searching Paper: Flip back and search by date Paper: Flip back and search by date
Electronic: Sort by date/code, or keyword search
Paper: Flip back and search by date
Electronic: Sort by date
Linking data Paper and electronic: Notes linked by date Paper and electronic: Notes linked by date Paper and electronic: Notes linked by date
Writing reports Electronic: Word/PowerPoint Electronic: Word/LaTeX Electronic: Word/LaTeX
Performing calculations and scientific functionality Paper: Solve
Electronic: Check (Excel/GraphPad)
Paper: Solve
Electronic: Check (Wolfram Alpha)
Paper: Solve
Electronic: Check (Excel/XMGrace/Spartan/PyPlots/R/CSV)
Use of technology in the lab (accessibility) Electronic: Phone pictures/recordings Electronic: Phone/camera pictures, emails, blogs, USB Electronic: Phone pictures/calendar, emails
Archiving and backup Paper: Mostly no backup (some photocopies)
Electronic: University computers/shared drives/the cloud/hard drives
Paper: Mostly no backup (some use carbon pages)
Electronic: University computers/shared drives/the cloud/hard drives
Paper: No backup (some photocopies)
Electronic: University computers/shared drives/the cloud/hard drives
Intellectual property Electronic: Secure data kept on hard drive in locked draw Electronic: No cloud software for industry-sponsored students Electronic: No cloud software for industry-sponsored students
Collaboration Paper: Lab book Paper: Lab book
Electronic: Shared drive/group folders
Electronic: Lab book
Electronic: Shared drive/group folders


The biologists and physicists from these focus groups were mostly uniform in their methods, whereas the chemists were more diverse, highlighting differences in their approach even within a single discipline.

Computational chemists used some software, with sporadic use of lab books and scraps of paper, whereas the "wet" chemists had stringently organized lab books for different tasks. One chemist used blogs and Word documents alongside their paper notebooks, and the crystallographers relied heavily on their paper sample books. The inorganic and organic chemists used paper lab notebooks during experiments, and only used lab computers to access the instruments they were linked to. Note-taking differed depending on the situation. For experiments, the lab book was typically used to record observations and initial values. The chemists recorded different types of data including energy values, simulations, temperature, masses, observations, schemas, and protocols. These findings have similarities to Reimer and Douglas’[43] work, illustrating how information recorded remained much the same; however, they also demonstrate that different chemists possess contrasting needs for recording their notes. Constructing one’s own "templates" or other mechanisms for standardizing data capture appears to be common in academic environments[44]; therefore, providing capabilities to facilitate this is likely to be popular.[13][44] Allowing users to edit their own templates poses challenges. This is illustrated by a comment from one of the lab observation participants, who resented being asked to use a template rather than expressing themselves in their own style.

Chemists also differed in how they linked their paper and electronic notes. The physicists and biologists linked them by date, whereas the chemists inconsistently used a variety of codes, reflecting the personal nature of note organization.[44] Despite their differing lab work, there was a common theme of using instruments (e.g., X-ray machines or diffractometers) to read data and linking statements in their lab book to reference electronic data location and any data values that required inputting to other software. In some situations it may be necessary to capture some information on paper, and ELNs therefore need to facilitate the inclusion of such information with the research record.

Different disciplines had varying restrictions on what equipment could be taken into the lab. The biologists didn’t have specific restrictions, although one biochemist mentioned that there were concerns about bringing in outside equipment in case of contamination. The physicists couldn’t bring equipment into their cleanroom to avoid contaminating the environment; contrastingly, the chemists wouldn’t take technology into the lab in order to avoid damaging it with chemicals. Computers in the lab weren’t often online, and most were connected to specific instruments. When asked, participants indicated a reluctance to use instrument-dedicated computers for any other purpose, such as making notes, accessing documents remotely, or using cloud software as they didn’t have network access. One chemist stated that "once you’ve started doing something one way, you don’t want to change it."


To investigate the participants' current searching and backup procedures, they were presented with three scenarios to discuss (illustrated in Fig. 6):

  • Imagine you’re trying to locate some work from six months ago. How would you locate you notes and associated data?
  • Imagine there’s a fire in your lab and all of your paper notebooks are destroyed. How much work would you lose and how could you go about recovering it?
  • If you fell under a bus tomorrow and were temporarily indisposed, how would your supervisor/industry sponsors/colleagues access your work?

For Scenario 1, participants revealed that they organized their lab books chronologically, and the most common method of locating previous work was to go back through their lab book by date to locate work from a particular time period. Similarly, to locate previous work on a computer, participants said that they would search by date to find the appropriate data files or would search by name if that proved unsuccessful.

Scenario 2 provoked different reactions. Some participants were unconcerned at the prospect of losing their lab books and thought reproducing what was needed wouldn’t take too long, as a lot of the information was only "useful in the moment" or a list of things that didn’t work. Whereas other participants elicited responses such as "I’d be ruined," "a nightmare," and "might as well stop my Ph.D. now." Particularly with reference to the idea of their labs catching fire, several participants seemed more concerned at the idea of losing their lab samples or compounds, suggesting that perhaps their lab books would not be the biggest loss in a fire.

Scenario 3 revealed that generally participants don’t have measures in place to enable their supervisors to access their work if something happened to them. One of the biologists had a particularly strict supervisor who required their students to photocopy all of their lab books and work, but that was a rare exception. It did however transpire that the participants believed that other group members would probably be able to access their work and give it to their supervisors, but they didn’t believe that they would be able to follow their lab books or the structures they’d put in place to link together their paper and electronic notes.

Fig6 Kanza JofCheminformatics2017 9.gif

Figure 6. Cartoon depicting three different scenarios: Scenario 1, Trying to search for some work/data six months later; Scenario 2, What would happen if your lab was set on fire and you lost everything in there?; and Scenario 3, If you were indisposed for a while how would your supervisor/research group access your work?

This continues the earlier theme about participants showing less concern towards backing up their paper-based work. They are obviously aware that these scenarios could occur, but the participants clearly don’t perceive the scenarios as likely or serious enough to merit much pre-emptive preparation, apart from circumstances where their supervisors have put procedures in place. Capturing notes and data electronically has clear backup and archiving benefits. Not only can electronic information be automatically backed up and securely stored, but the information can become accessible across multiple locations. Outdated information can be archived so that it can be retrieved later if needed, or be shared with other researchers through deposition or publication.

What do users want?

Having discussed with the users what they actually do, this section will look at what features the users say they want, with information taken from all studies B, D, E and F.

These have been grouped according to the different categories in the "What do users do?" section in addition to a new category of project activities that came out of this research. These features have also been linked to the associated priorities of the iLabber pilot project for those who found these features very or quite important, and it’s been noted which barriers these features aim to address.

The full breakdown of priorities from the iLabber Pilot Project are shown in Fig. 7.

Fig7 Kanza JofCheminformatics2017 9.gif

Figure 7. The main priorities of different ELN features from the respondents of the iLabber Pilot Project, ranging from whether respondents saw them as not important to very important


Based on the needs elicited from our user studies, we formulated a proposal of how to construct an ELN environment that would fit with these requirements. The majority of ELNs have been created from scratch, including the underlying "notebook" part[12][17][45]; an alternative would be to build on top of a generic electronic notebook (which are more popular than ELNs) with domain specific features. Many of these electronic notebooks already have collaborative cloud-based features and could be further expanded with domain knowledge and semantic web technologies. Additionally, based on our market research, despite the amount of available ELNs, there are a minority that are available as free/open-source platform-independent entities that scientists can use on any device, suggesting a gap that could be filled with this type of ELN.


As part of this vision, BioSistemika used their ELN survey to create their own ELN, sciNote.[46] Taking the path towards interoperability, sciNote has been designed in a modular way and released under an open source license (Mozilla Public Licence). Based on user needs, they are developing new add-ons while at the same time encouraging the community to develop their own add-ons, similar to the packages concept of R-statistical. In this way every lab will be able to design their own ELN to fit their needs, which will help them manage their project, share research, gather the metadata directly from instruments, and connect with existing software and databases.

Southampton University has looked at the features the users want (shown in Table 5) and formulated how these could be achieved using an electronic notebook platform as a base. There is a large overlap of features between electronic notebooks, ELNs, and SLNs, and the main features required by an ELN already exist in generic electronic notebooking software.[43] Furthermore, using a cloud-based electronic notebook platform would combat some of the accessibility issues and facilitate the collaboration requirements of the users, and incorporating semantic web technologies would provide an improved (semantic) search (the top priority listed in Fig. 7) and allow for metadata/tagging (as requested).

Table 5. These are the desired features elicited from the different user studies, linked to the priorities and barriers they relate to from the Dial-a-Molecule surveys
Category Desired features Priorities (DaM)/Addressing barriers
Recording notes Simple to install
Post-it notes
TODO lists
Create default values
Easy to write in as a paper notebook
Facilitate different experiments
Range of experiment templates
55.6%: Saving time over the paper notebook process is important
Barrier: Ease of use (3.2)
Organizing notes Indexable/highlightable
Contents table/overview screen/timeline
Tag/classify notes and experiments
Store metadata
Use of standard vocabularies (ontologies/measurement techniques)
80.2%: Improved quality of record keeping is important
Searching Keyword/filtered search
Data traceability
Advanced searches by chemical structure
Include reactions schemes in search results
Voice searches
Sortable results
90.6%: Improved ability to search and re-use documented information is important
Linking data Upload/link files, images and data files to notes
Link between different notebooks
Link to reference managers
Dropbox-esque features (automatic data update)
Automatically link to external chemistry resources
73.6%: Improve access to data as linked data through ELN is important
Barriers: Data compatibility and portability (3.6)
Writing reports "Generate Report" button to generate a publication ready report
Integrate and store different types of documents (Excel, Word, PDF, Pictures, Handwritten notes)
Copy sketches into notebook
Paper notebooks integration
Digital pen integration
Migration tools
Export functionality
Barrier: Software and system integration and compatibility (3.5)
Performing calculations and scientific functionality Perform calculations, formulas and equations as easily as paper
Create sketches and diagrams
Recognise a chemical when entered
Risk Assessment Templates/view electronically
Flags for dangerous chemicals
Index of COSHH materials
Global database of chemical values
Notifications for approvals
Sign off entries to make them non editable
60.4%: Easy inclusion of safety data is important
Use of technology in the lab (accessibility) Web Based/Platform Independent
Tablet/Smartphone Compliant
Text recognition, drawing and photo capabilities Usable in the lab like a paper notebook
Voice capture
Built in language for extensibility
79.3%: Access to notebook from more locations is important
Barrier: Access (3.4)
Archiving and backup Secure storage, backup and archives
87.8%: Secure automatic backup of data is important
Intellectual property Secure access
Different access levels for users
37.8%: Better protection of IP is important
Collaboration Shared files/notebooks
Standard list of instruments and reagents
Link related people and notebooks
Coordination for open source and access
Sign up and "get involved" pages
Configurable stand-alone to act as portals for projects and landing pages for collaborators
Enable users to find out who is working on similar molecules of reactions (requires inbuilt understanding of molecules)
63.2%: Better ability to collaborate and share information is important
Project activities Recent activity feed with notifications
Page statistics
Bulletin boards
Moderate comments
64.1%: Improved group/project management is important

A cloud-based ELN

There will always be concerns about IP with regards to using cloud-based services. The University of Southampton’s Lab Practice study elicited that users with industry sponsors were less likely to use cloud software. It is thought that once data is "in the cloud," users are no longer in control[47], and that like with any electronic service there is the potential for data breaches[48]; however, many precautions are taken. Yet this concern certainly isn’t restricted to electronic data. Some of the biologists from the University of Southampton’s Lab Practice Study said that they didn’t consider their work to be safe at conferences as people may take photographs of their posters and steal their ideas, and some of the chemists were aware that previous members of their research group had been "scooped" which resulted in tightened security measures across the group. Despite this, cloud computing is advantageous in that it can provide large volumes of storage and computing power that are accessible from any location[47][48], and it’s worth noting that only 18.9% of respondents in the iLabber Pilot Project Survey thought that "Better protection of IP" was "Very important," ranking significantly below "Improved search" and "Secure automatic backup of data," both of which lend themselves greatly to our proposed methods.

Proposed features/design

When investigating the features our users want, we realized that approximately 40% of these features are already implemented within cloud-based electronic notebooking software, and the rest of the features are either domain specific or could be achieved using semantic web technologies. Figure 8 shows these desired features elicited from our user studies detailed in Table 5, which are supported by previous ELN research work.[4][7][17][26][43][49][50]

Fig8 Kanza JofCheminformatics2017 9.gif

Figure 8. The desired features that have been elicited from the different user studies, categorized by whether they are features already included in a cloud based notebook, and then whether they fall into the category of an ELN domain specific feature or a semantic feature

We believe that this approach and the subsequent ELN environment that will be developed can mitigate the current barriers and concerns, as detailed in Table 6.

Table 6. How the proposed system could mitigate the barriers elicited from the Dial a Molecule iLabber Pilot Project: potential uses of ELNs in Academia Survey
Barrier Mitigation
Cost (3.1) ELN would be free.
Ease of use (3.2) Using a pre-existing electronic notebook would mean users are already familiar with the system, and rather than building the notebooking side from scratch it would use a tried and tested product.
Attitudes to ELNs (3.3) Adding a domain/semantic layer to software scientists already use might improve attitudes towards this type of ELN.
Access to ELNs (3.4) A cloud-based ELN can be accessed anywhere with an internet connection, on any desktop or mobile device (including phones and tablets).
Software and system integration and compatibility (3.5) Cloud software is platform independent.
Data compatibility and portability (3.6) Using cloud software to store data means it can be accessed across multiple devices. The cloud notebook would allow the user to export their research data in a variety of common data formats.

Therefore we propose that building a semantic ELN on top of an existing cloud infrastructure or platform would allow us to make use of these pre-existing features, provide a solid notebook base aligned with software scientists already use, and would also help combat the current adoption barriers. The ability to adapt documents and control input provided by a platform such as Google Docs enables much of the functionality needed for an ELN (e.g., in Fig. 9).

Fig9 Kanza JofCheminformatics2017 9.gif

Figure 9. An example of adding domain specific features to a pre-existing cloud notebook tool

Conclusions and future work

Our user studies have made one thing very clear: we cannot currently hope to fully replace the paper lab notebook. Until we have the technology where a screen can be written on as accurately and easily as paper, and labs have cheap, durable and easily replaceable tech to use instead of paper, it will always prevail for some tasks. We also need to stop thinking of ELNs as direct replacements for paper lab notebooks that are only useful during experiments in the lab and consider them in the wider context of the whole experiment process. Therefore we need to build a system that works with paper and formulate a new digital practice for scientists to use in their current lab environment.

Despite some scientists preferring paper notebooks, they still frequently use technology in their work. Many store data electronically and use note-taking software such as Word and Evernote to write up their notes, Excel to handle their figures and graphs, and specialty software for specific tasks. The cloud is also widely used to back up work and make it available across different locations. Therefore, we need to start considering ELNs that can work in this context and to work out how we can re-use existing successful software to create a better ELN platform.

We propose that we need an ELN environment that can serve as an interface between paper lab notebooks and the electronic documents that scientists create, one that is interoperable and utilizes semantic web and cloud technologies. It would fulfill all of the software needs described in the "What do users want?" section and provide a centralized location for scientists to store their notes. Whilst the ideal long term goal is that adoption of an ELN alongside extensive laboratory automation removes any need for paper, realistically current technology is such that it is desirable that ELN solutions work alongside paper for the foreseeable future. We believe that ELNS will significantly improve reproducibility of scientific experiments, contribute to data traceability and data annotation, and enable scientists to collaborate and share results in an intuitive manner. The wider adoption of ELNs will facilitate interoperability, which will ultimately change the ways scientists perform experiments and manage their data. There’s a great potential for future work in these areas, as an ELN that follows our vision has yet to be created. And as hardware and technology as a whole advances, we will be able to support even more of the experimental process digitally.


DaM: Dial-a-Molecule

ELN: electronic lab notebook

ELNs: electronic lab notebooks

IP: intellectual property

RDF: resource description framework

SLNs: semantic lab notebooks


Authors’ contributions

SK carried out Study C and Study D. CW carried out Study F and was involved with Study E alongside RW who designed and originated the survey. JE, KK and MH carried out Studies A and B. KZ/BioSistemika designed the surveys, did survey analysis and developed a concept of sciNote ELN together with MH. SK, CW and JE all contributed to writing the manuscript. NG and JGF helped draft and revise the manuscript, participated in the design of the research, and the analysis of the results. All authors read and approved the final manuscript.

Author information

SK is a final year iPh.D. Student in Web Science at the University of Southampton. Her primary research focus is Semantic Web technologies, and she is looking at bringing the modern power of the web to chemical research. She has a First Class M.Eng. Degree in Computer Science and worked as a software developer before starting her Ph.D. CW has recently completed a Ph.D. with Southampton University investigating note-taking behavior of scientists in the lab and the design of tools to help them capture and make use of their experiment information. Before undertaking research at Southampton, she worked at IBM UK Laboratories as a software engineer specializing in software usability and information architecture. NG is an associate Professor in Computer Science at the University of Southampton. His primary research interests are in the Semantic Web, hypertext, and distributed information systems. RW is a Professor of Organic Chemistry at the University of Southampton. He originated and leads the ‘Dial-a-Molecule’ Grand Challenge (, which has the 20–40 years aim of making the synthesis of new molecules as quick and easy as it currently is to order a commercial compound. He is interested in total synthesis, flow chemistry, molecular electronics, and cheminformatics. JGF is a Professor of Physical Chemistry at the University of Southampton. His interests span experimental laser spectroscopy and imaging, though chemical informatics and modelling, to the wider area e-science and digital economy. JE has a Ph.D. in Microbiology and Biotechnology. She always follows the latest trends in the Life sciences and believes that great software will be a crucial tool for wet lab or dry lab scientists in the near future. KZ has a Ph.D. in Genetics. He has created several successful companies and he strongly believes that platforms that are able to connect with your instruments and other software seamlessly will help in creating digital laboratories of the future. MH has a Ph.D. in Gene expression technologies. Based on his own experience, he has dedicated his career to developing new software products for researchers. KK has a Ph.D. in Virology. She has a special interest in laboratory management improvement and automation which would enable researchers dedicate more time to their research and innovation and leave tedious routine laboratory tasks to smart software and instruments.


We would like to thank all of the people who took part in the different user studies.

Competing interests

BioSistemika’s ELN Webinar Survey and ELN Survey were done as a part of the ELN market research before they started with the development of sciNote open-source electronic lab notebook. The results of BioSistemika’s market research complement nicely the data gathered by the University of Southampton. They highlight the current state of the ELN market and show in which direction — existing and new — ELN solutions should go in order to meet the expectations of the users. JGF is involved with the LabTrove ELN project (

Ethical approval and consent to participate

Specific ethical approval was obtained for Study 4 (the most recently conducted study). This study was approved by the University of Southampton’s Ethics Committee for the Faculty of Physical Sciences and Engineering. Focus groups—ethics application ERGO/FPSE/18246. Participant observations—ethics application ERGO/FPSE/18448.

Availability of data and materials

The datasets supporting the conclusions of this article will be available in the Pure repository for the University of Southampton, doi:10.5258/SOTON/405190. The datasets supporting the conclusions of this article are included within the article (and its Additional file 1).


This work was supported by the Web Science Centre for Doctoral Training at the University of Southampton, funded by the U.K. Engineering and Physical Sciences Research Council (EPSRC) under Grant No. EP/G036926/1. This work was also supported by the following groups: Digital Economy IT as a Utility Network + under Grant No. EP/K003569/1, the South East Regional e-Research Consortium under Grant No. EP/F05811X/1, and PLATFORM: End-to-End pipeline for chemical information: from the laboratory to literature and back again, under Grant No. EP/C008863/1. The Dial-a-Molecule work was also supported by the following Grants: EP/H034447/1 and EP/K004840/1. BioSistemika’s ELN Survey and Webinar were financed by BioSistemika LLC as a part of their ELN market research.

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Additional files as Additional file 1: A file describing how to access the focus groups and lab observations transcripts from Study D—University of Southampton Lab Practice Study (Focus Groups & Lab Observations).


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This presentation is faithful to the original, with only a few minor changes to presentation, including regionalizing spelling. In some cases important information was missing from the references, and that information was added. The original lists references in alphabetical order; this version lists them in order of appearance due to the nature of the wiki. Several URLs and access dates were also cleaned up from the original. The original question mark that appeared at the end of the title was removed from the wiki page title as it causes rendering issues elsewhere; the question mark was retained elsewhere.